168917-96-2Relevant academic research and scientific papers
Modified tert-butoxycarbonyl(m-BOC) derivatives as monomeric and polymeric aminoprotecting groups - VII
Gormanns, Marcus,Ritter, Helmut
, p. 3525 - 3534 (2007/10/02)
Polymerizable N-methacrylamino m-BOC-type, 1,1-dimethyl-2-methacrylmethanamido-ethoxy-carbonyl- and 1,1-dimethyl-3-methacrylmethanamido-butoxy-carbonyl group, derived from the corresponding t-alcohols have been developed as acid labile aminoprotecting groups. The synthesis of monomeric and polymeric N-methacrylamino m-BOC amino acids and amino acid methyl esters and their application for peptide synthesis following the (N→C)-assembly method are described. The rapid, acid induced cleavage of the protecting group leads to the formation of oxazole resp. oxazine derivatives.
