16892-50-5

Basic information

• Product Name: 8-thiabicyclo[3.2.1]octan-3-one
• Synonyms: 8-Thiabicyclo[3.2.1]octan-3-one
• CAS NO: 16892-50-5
• Molecular Formula: C₇H₁₀OS
• Molecular Weight: 142.2187
• Mol File: 16892-50-5.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 261.1°C at 760 mmHg
• Flash Point: 133.6°C
• Density: 1.195g/cm³
• Vapor Pressure: 0.0118mmHg at 25°C
• Refractive Index: 1.563
• CAS DataBase Reference: 8-thiabicyclo[3.2.1]octan-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 8-thiabicyclo[3.2.1]octan-3-one(16892-50-5)
• EPA Substance Registry System: 8-thiabicyclo[3.2.1]octan-3-one(16892-50-5)

Safety Data

• Hazardous Substances Data: 16892-50-5(Hazardous Substances Data)

Upstream product

• 532-24-1 tropinone 
• 532-24-1 tropinone 
• 6690-08-0 8,8-dimethyl-3-oxo-8-azonia-bicyclo[3.2.1]octane iodide 
• 163455-89-8 8-thiabicyclo[3.2.1]oct-2-en-3-yloxytrimethylsilane 
• 7732-18-5 water 
• 1192-93-4 cyclohepta-2,6-dienone 

Downstream Products

• 40698-01-9 8-Thiabicyclo<3.2.1>oct-2-en 
• 95054-50-5 3-Phenyl-8-thia-bicyclo[3.2.1]oct-2-ene 
• 106591-73-5 Toluene-4-sulfonic acid (1S,3S,5R)-(8-thia-bicyclo[3.2.1]oct-3-yl) ester 
• 95054-33-4 8-Methyl-3-phenyl-8-thionia-bicyclo[3.2.1]oct-2-ene; iodide 
• 90049-53-9 8-thia-bicyclo[3.2.1]octan-3-ol 

Relevant articles and documents

8-THIABICYCLOOCTAN-3-ONE AS A BIOCHEMICAL TOOL IN THE STUDY OF TROPANE ALKALOID BIOSYNTHESIS

8-Thiabicyclooctan-3-one, the sulphur analogue (replacing the methylaza bridge) of tropinone, was fed to Datura stramonium transformed root cultures.The compound was metabolized to a large degree.Notable products included the reduction product, 8-thiabicyclooctan-3-ol, analogous to tropine, and also the derived 3-O-acetyl ester.In addition, tropane alkaloid synthesis was perturbed.Hyoscyamine levels, and in particular tropine and 3α-acetoxytropane levels, were reduced.Pseudotropine, on the other hand, was found to increase in concentration.It is concluded that 8-thiabicyclooctan-3-one may be a good biochemical tool in the study of tropane alkaloid biosynthesis.Key Word Index -Datura stramonium; Solanaceae; biosynthesis; inhibitor; tropanealkaloids; tropine; pseudotropine; 8-thiabicyclooctan-3-one

Synthesis of 8-thiabicyclo[3.2.1]octanes and their binding affinity for the dopamine and serotonin transporters

Cocaine is a potent stimulant of the central nervous system. Its reinforcing and stimulant properties have been associated with inhibition of the dopamine transporter (DAT) on presynaptic neurons. In the search for medications for cocaine abuse, we have p

PHOTOACID GENERATOR, CHEMICALLY AMPLIFIED RESIST COMPOSITION, AND PATTERNING PROCESS

A photoacid generator having formula (1a) is provided. A chemically amplified resist composition comprising the PAG forms a pattern of rectangular profile with a good balance of sensitivity and LWR when processed by photolithography using ArF excimer lase

INDOLE CARBOXAMIDES AS IKK2 INHIBITORS

The invention is directed to novel indole carboxamide compounds. Specifically, the invention is directed to compounds according to formula (I): wherein R1, R2, R3, R4, and m are as defined herein. The compounds of the invention are inhibitors of IKK2 and can be useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKKβ) activity, such as rheumatoid arthritis, asthma, rhinitis, and COPD (chronic obstructive pulmonary disease). Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting IKK2 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.