168973-83-9Relevant academic research and scientific papers
HYDROXAMIC ACID AND CARBOXYLIC ACID DERIVATIVES, PROCESS FOR THEIR PREPARATION AND USE THEREOF
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, (2008/06/13)
This disclosure relates to a novel class of hydroxamic and carboxylic acid based matrix metalloproteinase inhibitor derivatives. The disclosure further relates to pharmaceutical compositions containing such compounds and to the use of such compounds and compositions in the treatment of matrix metalloproteinase induced diseases.
Inhibition of matrix metalloproteinases by hydroxamates containing heteroatom-based modifications of the P1' group
Gowravaram,Tomczuk,Johnson,Delecki,Cook,Ghose,Mathiowetz,Spurlino,Rubin,Smith,Pulvino,Wahl
, p. 2570 - 2581 (2007/10/02)
In this study, structure-based drug design of matrix metalloproteinase inhibitors [human fibroblast collagenase (HFC), human fibroblast stromelysin (HFS), and human neutrophil collagenase (HNC)] was utilized in the development of potent hydroxamates which
