168977-80-8Relevant academic research and scientific papers
Nonpeptide αvβ3 antagonists. Part 10: In vitro and in vivo evaluation of a potent 7-methyl substituted tetrahydro-[1,8]naphthyridine derivative
Breslin, Michael J.,Duggan, Mark E.,Halczenko, Wasyl,Hartman, George D.,Duong, Le T.,Fernandez-Metzler, Carmen,Gentile, Michael A.,Kimmel, Donald B.,Leu, Chih-Tai,Merkle, Kara,Prueksaritanont, Thomayant,Rodan, Gideon A.,Rodan, Sevgi B.,Hutchinson, John H.
, p. 4515 - 4518 (2004)
Subtle modifications were incorporated into the structure of clinical candidate 1. These changes were designed to maintain potency and selectivity while inducing changes in physical properties leading to improved pharmacokinetics in three species. This ap
Phosphinic acid analogues of GABA. 1. New potent and selective GABA(B) agonists
Froestl,Mickel,Hall,Von Sprecher,Strub,Baumann,Brugger,Gentsch,Jaekel,Olpe,Rihs,Vassout,Waldmeier,Bittiger
, p. 3297 - 3312 (2007/10/02)
The antispastic agent and muscle relaxant baclofen 1 is a potent and selective agonist for bicuculline-insensitive GABA(B) receptors. For many years efforts to obtain superior GABA(B) agonists were unsuccessful. We describe the syntheses and biological pr
