748814-06-4Relevant academic research and scientific papers
Nonpeptide αvβ3 antagonists. Part 10: In vitro and in vivo evaluation of a potent 7-methyl substituted tetrahydro-[1,8]naphthyridine derivative
Breslin, Michael J.,Duggan, Mark E.,Halczenko, Wasyl,Hartman, George D.,Duong, Le T.,Fernandez-Metzler, Carmen,Gentile, Michael A.,Kimmel, Donald B.,Leu, Chih-Tai,Merkle, Kara,Prueksaritanont, Thomayant,Rodan, Gideon A.,Rodan, Sevgi B.,Hutchinson, John H.
, p. 4515 - 4518 (2007/10/03)
Subtle modifications were incorporated into the structure of clinical candidate 1. These changes were designed to maintain potency and selectivity while inducing changes in physical properties leading to improved pharmacokinetics in three species. This ap
