16899-18-6 Usage
Uses
Used in Pharmaceutical Industry:
L-2-AMinothiazoline-4-carboxylic Acid is used as an intermediate in the synthesis of various pharmaceutical compounds for its ability to be converted to L-cysteine, which is an essential amino acid involved in various biological processes.
Used in Biochemical Research:
L-2-AMinothiazoline-4-carboxylic Acid is used as a research tool in the study of enzyme mechanisms and the role of L-cysteine in cellular processes, particularly in the context of bacterial metabolism and the action of ATCase.
Used in Bacterial Metabolism Studies:
L-2-AMinothiazoline-4-carboxylic Acid is used as a substrate in the investigation of the enzyme 2-amino-Δ2-thiazoline-4-carboxylic acid hydrolase (ATCase) and its role in the conversion of L-2-AMinothiazoline-4-carboxylic Acid to L-cysteine in certain bacteria, providing insights into bacterial metabolism and potential targets for antibiotic development.
Check Digit Verification of cas no
The CAS Registry Mumber 16899-18-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,8,9 and 9 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 16899-18:
(7*1)+(6*6)+(5*8)+(4*9)+(3*9)+(2*1)+(1*8)=156
156 % 10 = 6
So 16899-18-6 is a valid CAS Registry Number.
16899-18-6Relevant academic research and scientific papers
Methods Of Stapling And Unstapling Peptides And Proteins
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Paragraph 0070; 0071, (2016/01/25)
The present disclosure pertains to the field peptide stapling and/or macrocyclization, where a structural motif is used to improve the properties of amino acid sequences (e.g. protease resistance, cellular penetration, biological activity). Also within th
Peptide/protein stapling and unstapling: Introduction of s-tetrazine, photochemical release, and regeneration of the peptide/protein
Brown, Stephen P.,Smith, Amos B.
supporting information, p. 4034 - 4037 (2015/04/14)
Protocols have been achieved that permit facile introduction of s-tetrazine into unprotected peptides and the protein, thioredoxin, between two cysteine sulfhydryl groups (i.e., staple), followed by photochemical release (i.e., unstaple) and regeneration of the peptide/protein upon removal of the cyano groups from the derived bisthiocyanate. The S,S-tetrazine macrocycles in turn provide a convenient handle for probe introduction by exploiting the inverse electron demand Diels-Alder reactivity of the tetrazine.
