169045-07-2

Upstream product

• 1074-82-4 potassium phtalimide 
• 3360-45-0 4-chloro-3-nitro-benzylbromide 
• 3771-13-9 2-(bromomethyl)-1-chloro-4-methoxybenzene 
• 38185-19-2 4-(methylthio)benzyl bromide 
• 23145-65-5 1-bromomethyl-3-methoxy-4-nitrobenzene 
• 103347-14-4 4-(bromomethyl)-1-chloro-2-methoxybenzene 
• 79440-34-9 6-(bromomethyl)-2,3-dihydrobenzo[b][1,4]dioxine 
• 17201-43-3 4-cyanobenzyl bromide 
• 54788-17-9 2-chloro-4-methoxybenzyl bromide 
• 223645-48-5 1-(bromomethyl)-4-bis(tert-butoxycarbonyl)amino-3-chlorobenzene 
• 105-07-7 4-cyanobenzaldehyde 
• 89-60-1 1-chloro-4-methyl-2-nitro-benzene 
• 67341-33-7 2,6-dichloro-4-methylanisole 
• 73909-16-7 2-chloro-5-methylanisole 

Downstream Products

• 247569-42-2 (4-chloro-3-methoxyphenyl)methanamine 
• 247568-43-0 2-[1-(tert-butoxycarbonyl)-4-piperidinylamino]-5-nitro-N-(1,3-benzodioxol-5-ylmethyl)benzamide 
• 247566-98-9 2-(1-Benzylpiperidin-4-ylamino)-5-nitro-N-(1,3-benzodioxol-5-ylmethyl)benzamide 
• 247566-97-8 2-[1-(Ethoxycarbonyl)piperidin-4-ylamino]-5-nitro-N-(1,3-benzodioxol-5-ylmethyl)benzamide 
• 247568-42-9 2-(4-carboxycyclohexylamino)-5-nitro-N-(1,3-benzodioxol-5-ylmethyl)benzamide 
• 247568-41-8 2-[4-(methoxycarbonyl)cyclohexylamino]-5-nitro-N-(1,3-benzodioxol-5-ylmethyl)benzamide 
• 247567-04-0 2-[1-(Hydroxymethyl)cyclopentylamino]-5-nitro-N-(1,3-benzodioxol-5-ylmethyl)benzamide 
• 247566-99-0 2-[2-Hydroxy-1,1-bis(hydroxymethyl)ethylamino]-5-nitro-N-(1,3-benzodioxol-5-ylmethyl)benzamide 
• 247567-06-2 2-[1-(1-Hydroxymethyl)pentylamino]-5-nitro-N-(1,3-benzodioxol-5-ylmethyl)benzamide 
• 247567-03-9 2-(1-Formyl-4-piperidinylamino)-5-nitro-N-(1,3-benzodioxol-5-ylmethyl)benzamide 
• 247566-80-9 5-nitro-2-(4-oxocyclohexylamino)-N-(1,3-benzodioxol-5-ylmethyl)benzamide 
• 247566-94-5 2-[(1R,2R)-2-Hydroxy-1-(hydroxymethyl)propylamino]-5-nitro-N-(1,3-benzodioxol-5-ylmethyl)benzamide 
• 247568-44-1 5-nitro-2-(4-piperidinylamino)-N-(1,3-benzodioxol-5-ylmethyl)benzamide 
• 247566-90-1 (S)-2-[2-Hydroxy-1-(methoxycarbonyl)ethylamino]-5-nitro-N-(1,3-benzodioxol-5-ylmethyl)benzamide 

Relevant academic research and scientific papers

CHEMICAL COMPOUNDS

The present invention relates to compounds that are a non-nucleoside reverse transcriptase inhibitors, and to processes for the preparation and use of the same. Specifically, the present invention includes methods of using such compounds in the treatment of human immunodeficiency virus infection.

Anthranilic acid derivatives as inhibitors of the cGMP-phosphodiesterase

Compounds of formula (I) STR1where R 1 is hydrogen; R 2 is nitro, cyano or halo(lower)alkyl; R 3 is phenyl substituted with one or more substituents selected from halogen, cyano and lower alkoxy; A is a lower alkylene group; R 4 is a group CR 6 R 7 R 8 wherein R 6 and R 7 form, together with the carbon atom to which they are attached a cycloalkyl group optionally substituted with hydroxy, lower alkoxy or a lower alkanoylamino; and R 8 is hydrogen; its prodrug and a salt thereof.