169048-79-7

Basic information

• Product Name: 2-Oxazolidinone, 5-(chloroMethyl)-, (5R)-
• Synonyms: 2-Oxazolidinone, 5-(chloroMethyl)-, (5R)-;(R)-5-ChloroMethyl-2-oxazolidinone;(R)-5-(chloromethyl)oxazolidin-2-one;(5R)-5-(chloromethyl)-1,3-oxazolidin-2-one
• CAS NO: 169048-79-7
• Molecular Formula: C₄H₆ClNO₂
• Molecular Weight: 135.54894
• Mol File: 169048-79-7.mol
• Article Data: 13

Chemical Properties

• Melting Point: 75-77 °C
• Boiling Point: 382.8±11.0 °C(Predicted)
• Appearance: /
• Density: 1.294±0.06 g/cm3(Predicted)
• PKA: 12.09±0.40(Predicted)
• CAS DataBase Reference: 2-Oxazolidinone, 5-(chloroMethyl)-, (5R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Oxazolidinone, 5-(chloroMethyl)-, (5R)-(169048-79-7)
• EPA Substance Registry System: 2-Oxazolidinone, 5-(chloroMethyl)-, (5R)-(169048-79-7)

Safety Data

• Hazardous Substances Data: 169048-79-7(Hazardous Substances Data)

Usage

General Description

2-Oxazolidinone, 5-(chloromethyl)-, (5R)- is a chemical compound that belongs to the oxazolidinone class of compounds. It is a stereoisomer with a specific chirality, denoted as (5R)-, indicating its configuration within the molecule. 2-Oxazolidinone, 5-(chloromethyl)-, (5R)- contains a chloride group attached to the 5th position of the oxazolidinone ring, which gives it unique chemical properties and reactivity. It may be used as a building block in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds due to its versatile nature and reactivity in organic reactions. Its specific stereochemistry and functional groups make it a valuable intermediate in organic synthesis.

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Relevant articles and documents

Synthesis and biological activity evaluation of novel heterocyclic pleuromutilin derivatives

A series of pleuromutilin derivatives were synthesized by two synthetic procedures under mild reaction conditions and characterized by Nuclear Magnetic Resonance (NMR), Infrared Spectroscopy (IR), and High Resolution Mass Spectrometer (HRMS). Most of the derivatives with heterocyclic groups at the C-14 side of pleuromutilin exhibited excellent in vitro antibacterial activities against Staphylococcus aureus, methicillin-resistant Staphylococcus aureus (MRSA), methicillin-resistant Staphylococcus epidermidis (MRSE), and vancomycin-resistant Enterococcus (VRE) in vitro antibacterial activity. The synthesized derivatives which contained pyrimidine rings, 3a, 3b, and 3f, displayed modest antibacterial activities. Compound 3a, the most active antibacterial agent, displayed rapid bactericidal activity and affected bacterial growth in the same manner as that of tiamulin fumarate. Moreover, molecular docking studies of 3a and lefamulin provided similar information about the interactions between the compounds and 50S ribosomal subunit. The results of the study show that pyrimidine rings should be considered in the drug design of pleuromutilin derivatives.

BICYCLIC HETEROARYL SUBSTITUTED COMPOUNDS

Disclosed are compounds of Formula (I) to (VIII): (I) (II) (III) (IV) (V) (VI) (VII) (VIII); or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate or prodrug thereof, wherein R3 is a bicyclic heteroaryl group substituted with zero to 3 R3a; and R1, R2, R3a, R4, and n are defined herein. Also disclosed are methods of using such compounds as PAR4 inhibitors, and pharmaceutical compositions comprising such compounds. These compounds are useful in inhibiting or preventing platelet aggregation, and are useful for the treatment of a thromboembolic disorder or the primary prophylaxis of a thromboembolic disorder.

A facile synthesis of the oxazolidinone antibacterial agent linezolid

A facile synthetic route of linezolid 1 has been developed. Using commercially available (R)-epichlorohydrin as the starting material, 1 was obtained through a sequence of cyclization, substitution, a Goldberg coupling, aminolysis and acetylation reactions. The synthetic route is easy to perform and can be scaled up.