169059-74-9

Upstream product

• 84246-49-1 2(S)-2-(benzyloxycarbonylamino)-6-hydroxyhexanoic acid, benzyl ester 
• 102922-72-5 (S)-2-(((benzyloxy)carbonyl)amino)-6-hydroxyhexanoic acid 
• 2212-75-1 N₂-[(benzyloxy)carbonyl]-L-lysine 

Downstream Products

• 1453205-06-5 C₂₄H₂₈N₂O₄ 
• 1453205-07-6 C₂₅H₃₀N₂O₄ 

Relevant academic research and scientific papers

Preparation of amino- and carboxy-protected L-α-amino-ω-iodocarboxylic acids

The synthesis of L-α-amino-ω-iodobutyric, valeric, and caproic acid esters protected at the amino function by a benzyloxycarbonyl group is reported.

Nonpeptidic propargylamines as inhibitors of lysine specific demethylase 1 (LSD1) with cellular activity

Lysine demethylases play an important role in epigenetic regulation and thus in the development of diseases like cancer or neurodegenerative disorders. As the lysine specific demethylase 1 (LSD1/KDM1) has been strongly connected to androgen and estrogen dependent gene expression, it serves as a promising target for the therapy of hormone dependent cancer. Here, we report on the discovery of new small molecule inhibitors of LSD1 containing a propargylamine warhead, starting out from lysine containing substrate analogues. On the basis of these substrate mimicking inhibitors, we were able to increase potency by a combination of similarity-based virtual screening and subsequent synthetic optimization resulting in more druglike LSD1 inhibitors that led to histone hypermethylation in breast cancer cells.