169114-07-2

Upstream product

• 103-89-9 4-Methylacetanilide 
• 106-49-0 p-toluidine 
• 612-03-3 4-(N-methylacetamido)toluene 
• 169114-06-1 N-(4-(hydroxymethyl)phenyl)-N-methylacetamide 

Downstream Products

• 64563-12-8 C₁₉H₂₆N₂O₆ 

Relevant academic research and scientific papers

Carbonylative Coupling of Alkyl Zinc Reagents with Benzyl Bromides Catalyzed by a Nickel/NN2 Pincer Ligand Complex

An efficient catalytic protocol for the three-component assembly of benzyl bromides, carbon monoxide, and alkyl zinc reagents to give benzyl alkyl ketones is described, and represents the first nickel-catalyzed carbonylative coupling of two sp3-carbon fragments. The method, which relies on the application of nickel complexed with an NN2-type pincer ligand and a controlled release of CO gas from a solid precursor, works well with a range of benzylic bromides. Mechanistic studies suggest the intermediacy of carbon-centered radicals.

Carbocation Catalyzed Bromination of Alkyl Arenes, a Chemoselective sp3 vs. sp2 C?H functionalization.

The versatility of the trityl cation (TrBF4) as a highly efficient Lewis acid organocatalyst is demonstrated in a light induced benzylic brominaion of alkyl-arenes under mild conditions. The reaction was conducted at ambient temperature under common hood light (55 W fluorescent light) with catalyst loadings down to 2.0 mol% using N-bromosuccinimide (NBS) as the brominating agent. The protocol is applicable to an extensive number of substrates to give benzyl bromides in good to excellent yields. In contrast to most previously reported strategies, this protocol does not require any radical initiator or extensive heating. For electron-rich alkyl-arenes, the trityl ion catalyzed bromination could be easily switched between benzylic sp3 C?H functionalization and arene sp2 C?H functionalization by simply alternating the solvent. This chemoselective switch allows for high substrate control and easy preparation of benzyl bromides and bromoarenes, respectively. The chemoselective switch was also applied in a one-pot reaction of 1-methylnaphthalene for direct introduction of both sp3 C?Br and sp2 C?Br functionality. (Figure presented.).

Mild chemical and biological synthesis of donor-acceptor flanked reporter stilbenes: Demonstration of a physiological wittig olefination reaction

Unprecedented chemoselectivity is reported for the Wittig olefination reaction leading to the formation of reporter stilbenes under physiological conditions.

COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACIDS AND POLYPEPTIDES

Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one aromatic amine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one alkylated amine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.

Pyran-4-ylmethyl substituted arylalkylaryl-, arylalkenylylaryl-, and arylalkynylarylurea inhibitors of 5-lipoxygenase

Compounds of structure STR1 where W is selected from STR2 where Q is oxygen or sulfur, R5 and R6 are independently selected from hydrogen and alkyl, or R5 and R6, together with the nitrogen atoms to which they a

Heteroatom substituted propanyl derivatives having 5-lipoxygenase inhibitory activity

Compounds of the structure STR1 where R1 is alkyl of one to four carbon atoms and R2 is selected from (a) alkenyl of one to four carbon atoms, (b) STR2 (c) STR3 and (d) STR4 are potent inhibitors of lipoxygenase enzymes and thus inhibit the biosynthesis of leukotrienes. These compounds are useful in the treatment or amelioration of allergic and inflammatory disease states.

TRANS-1,4-DIALKOXYCYCLOHEXYL SUBSTITUTED ARYLALKYLARYL- ARYLALKENYLARYL-, AND ARYLALKYNYLARYLUREA INHIBITORS OF 5-LIPOXYGENASE

Compounds of stracture where W is selected from the group consisting of where Q is oxygen or sulfur, R7 and R8 are independently selected from hydrogen and alkyl, or R7 and R8, together with the nitrogen atoms to which they are attached, define a radical