612-03-3

Basic information

• Product Name: N-methyl-N-(4-methylphenyl)acetamide
• Synonyms: N-methyl-N-(4-methylphenyl)acetamide;4',N-Dimethylacetoanilide;N-(4-Methylphenyl)-N-methylacetamide;N-Methylaceto-p-toluidide;N-Methyl-N-(p-tolyl)acetamide;N-Methyl-N-p-tolylacetamide
• CAS NO: 612-03-3
• Molecular Formula: C₁₀H₁₃NO
• Molecular Weight: 163.22
• Mol File: 612-03-3.mol
• Article Data: 23

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-methyl-N-(4-methylphenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-methyl-N-(4-methylphenyl)acetamide(612-03-3)
• EPA Substance Registry System: N-methyl-N-(4-methylphenyl)acetamide(612-03-3)

Safety Data

• Hazardous Substances Data: 612-03-3(Hazardous Substances Data)

Usage

General Description

N-methyl-N-(4-methylphenyl)acetamide, also known as methyl-4-methylanilide, is an organic compound with the chemical formula C10H13NO. It is a white solid commonly used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. This chemical is classified as an amide, containing a carbonyl group linked to a nitrogen atom and a methyl group attached to the nitrogen. It is an important building block in the production of various drugs and is also used as a solvent in organic synthesis. N-methyl-N-(4-methylphenyl)acetamide is considered a stable and relatively non-reactive compound when handled and stored properly.

Upstream product

• 108-24-7 acetic anhydride 
• 99-97-8 Dimethyl-p-toluidine 
• 103-89-9 4-Methylacetanilide 
• 3847-19-6 2-acetoxypyridine 
• 35113-87-2 N-ethyl-N-methyl-4-methylaniline 
• 74-88-4 methyl iodide 
• 75-36-5 acetyl chloride 
• 693803-44-0 tert-butyl N-p-tolyl-N-methylcarbamate 
• 64-19-7 acetic acid 
• 62404-59-5 4-(N-acetyl-N-methylamino)iodobenzene 
• 80-48-8 methyl p-toluene sulfonate 
• 201230-82-2 carbon monoxide 
• 80-43-3 bis(1-methyl-1-phenylethyl)peroxide 
• 106-49-0 p-toluidine 

Downstream Products

• 62323-65-3 4,N-dimethyl-2,6,N-trinitro-aniline 
• 35113-87-2 N-ethyl-N-methyl-4-methylaniline 
• 1173504-72-7 N-methyl-N-(4-methyl-2-((triisopropyisilyl)ethynyl)phenyl)acetamide 
• 1319751-61-5 N-methyl-4-methyl-α-bromoacetanilide 
• 15753-42-1 4',N-Dimethyl-thioacetanilid 
• 623-08-5 N-methyl-p-toluidine 
• 87995-51-5 N-(2-bromo-4-methylphenyl)-N-methylacetamide 
• 169114-07-2 N-(4-(bromomethyl)phenyl)-N-methylacetamide 

Relevant articles and documents

Method for promoting acylation of amine or alcohol by carbon dioxide

The invention relates to a method for promoting acylation of amine or alcohol by carbon dioxide, which comprises the following steps of: mixing an amine compound, carboxylate or thiocarboxylate compound and a reaction solvent under the action of carbon dioxide, and reacting to obtain an amide compound, or under the action of carbon dioxide, mixing the alcohol compound, the thiocarboxylate compound and the reaction solvent [gamma]-valerolactone, and reacting to obtain the ester compound. According to the invention, under the promotion action of carbon dioxide, carboxylate or thiocarboxylate is used as an acylation reagent, and amine and alcohol are converted into amide and ester compounds in the absence of a transition metal catalyst, so that acylation reagents such as acyl chloride or anhydride with irritation and corrosivity are avoided; and the method has the advantages of simple operation, mild reaction conditions, high tolerance of substrate functional groups, strong applicability and high yield, and provides an efficient, reliable and economical preparation method for synthesis of amide and ester compounds.

Amide Bond Formation Catalyzed by Recyclable Copper Nanoparticles Supported on Zeolite Y under Mild Conditions

A series of catalysts based on supported copper nanoparticles have been prepared and tested in the amide bond formation from tertiary amines and acid anhydrides, in the presence of tert-butyl hydroperoxide as an oxidant. Copper nanoparticles on zeolite Y (CuNPs/ZY) was found to be the most efficient catalyst for the synthesis of amides, working in acetonitrile as solvent, under ligand- and base-free conditions in air. The products were obtained in good to excellent yields and in short reaction times. The CuNPs/ZY system also exhibited higher catalytic activity than some commercially available copper and iron sources and it was reused in ten reaction cycles without any further pre-treatment. This methodology has been successfully scaled-up to a gram scale with no detriment to the yield.

Nickel and Nucleophilic Cobalt-Catalyzed Trideuteriomethylation of Aryl Halides Using Trideuteriomethyl p-Toluenesulfonate

Herein, a novel approach for the trideuteriomethylation of aryl halides using nickel and nucleophilic cobalt catalysts and the readily available trideuteriomethyl p-toluenesulfonate (CD3OTs) is described. This method provides access to a wide r