169138-05-0

Upstream product

• 113965-64-3 1,1,1-Trifluoro-3-((R)-toluene-4-sulfinyl)-propan-2-one 
• 1519-39-7 (R)-methyl p-tolyl sulfoxide 
• 182880-39-3 (4-Methoxy-phenyl)-[(S)-2,2,2-trifluoro-1-((R)-toluene-4-sulfinylmethyl)-ethyl]-amine 
• 169137-94-4 (Z)-2-((R)-Toluene-4-sulfinyl)-1-trifluoromethyl-vinylamine 

Downstream Products

• 169138-02-7 [(S)-2,2,2-Trifluoro-1-((R)-toluene-4-sulfinylmethyl)-ethyl]-carbamic acid benzyl ester 
• 177268-09-6 (S)-2,2,2-Trifluoro-1-p-tolylsulfanylmethyl-ethylamine 

Relevant academic research and scientific papers

New versatile fluorinated chiral building blocks: Synthesis and reactivity of optically pure α-(fluoroalkyl)-β-sulfinylenamines

Efficient synthesis of optically pure α-(fluoroalkyl)-β-sulfinyl enamines has been achieved by aza-Wittig reaction of triphenyliminophosphoranes with the corresponding α-fluorinated-α'-sulfinyl ketones. The title compounds 3,4 showed an overwhelming prefe

Stereoselective synthesis of optically pure γ-fluoro-βenaminosulfoxides and reduction to γ-fluoro-βaminosulfoxides

The aza-Wittig reaction of phospha-λ5-azenes with optically pure γ-fluorosubstituted β-ketosulfoxides leads to the corresponding β-enaminosulfoxides, which were easily isolated in diastereomerically pure form. The stereoselective reduction of t

Unusual Non-Oxidative Pummerer Rearrangement of γ-Trifluoro-β-aminosulfoxides

Trifluoroacetic anhydride promoted Pummerer rearrangement of γ-trifluoro-β-aminosulfoxides 1 follows an unusual pathway, in which a migration of the p-tolylthio group to the nitrogen atom provides the corresponding α-sulfenamidotrifluoroacetates 5.The usu