169140-88-9

Upstream product

• 123-75-1 pyrrolidine 
• 104-53-0 3-phenyl-propionaldehyde 
• 6160-65-2 1,1'-Thiocarbonyldiimidazole 

Downstream Products

• 1312026-00-8 (-)-O-(3R,5S)-5-(tert-butoxycarbonyl)amino-6-(1H-indol-3-yl)-4-oxo-1-phenylhexan-3-yl pyrrolidine-1-carbothioate 
• 1312025-97-0 (-)-(4S,6R)-benzyl 4-(tert-butoxycarbonyl)amino-5-oxo-8-phenyl-6-[(pyrrolidine-1-carbonothioyl)oxy]octanoate 
• 1312025-92-5 (-)-O-(3R,5S)-5-(tert-butoxycarbonyl)amino-4-oxo-1,6-diphenylhexan-3-yl pyrrolidine-1-carbothioate 
• 128414-07-3 (-)-tert-butyl (2S,3R,4R)-3,4-dihydroxy-1,6-diphenylhexan-2-ylcarbamate 
• 1312025-89-0 (-)-O-(3R,5S)-5-(tert-butoxycarbonyl)amino-4-oxo-1,6-diphenylhexan-3-yl pyrrolidine-1-carbothioate 
• 1312025-95-8 (+)-O-(3S,5S)-5-(tert-butoxycarbonyl)amino-7-methylthio-4-oxo-1-phenylheptan-3-yl pyrrolidine-1-carbothioate 

Relevant academic research and scientific papers

Synthesis of enantioenriched α-(hydroxyalkyl)-tri-n-butylstannanes

(Chemical Equation Presented) Li and Mg are pesky: A catalytic asymmetric synthesis of α-(hydroxyalkyl)-tri-n-butylstannanes (1) in good to excellent yields and enantioselectivities was achieved (see scheme; PG=protecting group; L=chiral ligand). Compound 1 was isolated as an ester or thiocarbamate, and the reagent was prepared from equimolar amounts of nBu3SnH and Et2Zn in dimethoxyethane. Conditions employing lithium or magnesium ions suppress enantioselectivity.