169189-80-4

Basic information

• Product Name: 2-Bromo-N-ethylbenzenesulphonamide
• Synonyms: 2-Bromo-N-ethylbenzenesulphonamide;2-Bromo-N-ethylbenzenesulfonamide;N-Ethyl 2-bromobenzenesulfonamide
• CAS NO: 169189-80-4
• Molecular Formula: C₈H₁₀BrNO₂S
• Molecular Weight: 264.14
• Product Categories: blocks;Bromides;Sulfonamides
• Mol File: 169189-80-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 353.183 °C at 760 mmHg
• Flash Point: 167.4 °C
• Appearance: /
• Density: 1.529 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.564
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-Bromo-N-ethylbenzenesulphonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-N-ethylbenzenesulphonamide(169189-80-4)
• EPA Substance Registry System: 2-Bromo-N-ethylbenzenesulphonamide(169189-80-4)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 169189-80-4(Hazardous Substances Data)

Usage

General Description

2-Bromo-N-ethylbenzenesulphonamide is a chemical compound that belongs to the class of sulfonamide compounds. It is an N-alkyl sulfonamide derivative, which means that it contains a sulfonamide group attached to an ethyl group via a nitrogen atom. The presence of a bromine atom also gives this compound its distinct properties. This chemical is commonly used as a pharmaceutical intermediate and in the synthesis of other compounds. It has also been studied for its potential biological activities and has been shown to exhibit antimicrobial properties. Additionally, it can be used as a reagent in organic chemistry reactions and as a building block for the synthesis of more complex molecules.

InChI:InChI=1/C8H10BrNO2S/c1-2-10-13(11,12)8-6-4-3-5-7(8)9/h3-6,10H,2H2,1H3

Upstream product

• 2905-25-1 o-bromobenzenesulfonyl chloride 
• 75-04-7 ethylamine 

Downstream Products

• 1269616-19-4 2-bromo-N-ethyl-N-(prop-2-ynyl)benzenesulfonamide 
• 929205-81-2 N-ethyl-2-hept-1-ynyl-benzenesulfonamide 

Relevant articles and documents

Regio- and Stereoselective Synthesis of Benzo-δ-sultams by Palladium-Catalyzed Hydrocarbonation of Alkynes

An efficient method for the synthesis of benzo-δ-sultams [(4Z)-4-benzylidene-2-(arylmethyl)-3,4-dihydro-2H-1,2-benzothiazine 1,1-dioxides] via palladium(0)-catalyzed hydrocarbonation of alkynes is presented. This method allows regioselective access to a variety of substituted benzosultams in excellent yields under mild conditions. The stereochemistry of the exocyclic double bond of the benzosultam derivatives is confirmed by single-crystal X-ray diffraction.

Lewis acid catalyzed cascade reaction of 3-(2-benzenesulfonamide)propargylic alcohols to spiro[indene-benzosultam]s

A highly efficient and convenient construction of the spiro[indene-benzosultam] skeleton from propargylic alcohols has been developed. The reaction proceeded in a Lewis acid catalyzed cascade process, including the trapping of allene carbocation with sulfonamide, electrophilic cyclization, and intramolecular Friedel-Crafts alkylation. In the presence of NIS or NBS, iodo/bromo-substituted spiro[indene-benzosultam]s could be prepared in excellent yields.

Regioselective construction of six-membered fused heterocyclic rings via Pd/C-mediated C-C coupling followed by iodocyclization strategy: a new entry to 2H-1,2-benzothiazine-1,1-dioxides

We describe a practical and elegant method of constructing a thiazine ring fused with benzene under mild reaction conditions. A?variety of 4-iodo-2H-benzo[e][1,2]thiazine-1,1-dioxides were prepared with high regioselectivity via a two-step process involvi