1692-02-0

Basic information

• Product Name: (4-FLUORO-BENZYL)-PYRIDIN-2-YL-AMINE DIHYDROCHLORIDE
• Synonyms: (4-FLUORO-BENZYL)-PYRIDIN-2-YL-AMINE DIHYDROCHLORIDE;N-(4-Fluorobenzyl)pyridin-2-aMine dihydrochloride
• CAS NO: 1692-02-0
• Molecular Formula: C₁₂H₁₁FN₂
• Molecular Weight: 275.1494232
• Mol File: 1692-02-0.mol

Chemical Properties

• Boiling Point: 326.6±22.0 °C(Predicted)
• Appearance: /
• Density: 1.210±0.06 g/cm3(Predicted)
• PKA: 6.21±0.10(Predicted)
• CAS DataBase Reference: (4-FLUORO-BENZYL)-PYRIDIN-2-YL-AMINE DIHYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (4-FLUORO-BENZYL)-PYRIDIN-2-YL-AMINE DIHYDROCHLORIDE(1692-02-0)
• EPA Substance Registry System: (4-FLUORO-BENZYL)-PYRIDIN-2-YL-AMINE DIHYDROCHLORIDE(1692-02-0)

Safety Data

• Hazardous Substances Data: 1692-02-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(4-FLUORO-BENZYL)-PYRIDIN-2-YL-AMINE DIHYDROCHLORIDE is used as a building block for the development of various pharmaceuticals and biologically active molecules, particularly targeting neurological disorders and infectious diseases. Its unique structure allows for the creation of compounds with potential therapeutic effects against these conditions.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (4-FLUORO-BENZYL)-PYRIDIN-2-YL-AMINE DIHYDROCHLORIDE is employed as a reagent to introduce the (4-fluoro-benzyl) and pyridin-2-yl-amine groups into molecules. This functionalization can lead to the discovery of new drugs with improved pharmacological properties and enhanced efficacy.
Used in Organic Synthesis:
(4-FLUORO-BENZYL)-PYRIDIN-2-YL-AMINE DIHYDROCHLORIDE is also used in organic synthesis as a versatile building block. Its incorporation into various molecular structures can result in the creation of novel compounds with diverse applications, including potential uses in materials science, agrochemicals, and other specialty chemical industries.

Upstream product

• 372-48-5 2-fluoropyridine 
• 140-75-0 para-fluorobenzylamine 
• 504-29-0 2-aminopyridine 
• 38427-94-0 N-(tert-butoxycarbonyl)-2-aminopyridine 
• 1445435-43-7 C₁₇H₁₉FN₂O₂ 
• 462-08-8 pyridin-3-ylamine 
• 459-57-4 4-fluorobenzaldehyde 
• 459-56-3 4-fluorobenzylic alcohol 
• 104-87-0 4-methyl-benzaldehyde 
• 352-11-4 1-chloromethyl-4-fluorobenzene 

Downstream Products

• 396-59-8 N-(4-fluoro-benzyl)-N',N'-dimethyl-N-[2]pyridyl-ethylenediamine 
• 136343-75-4 8-fluoropyrido[1,2-a]benzimidazole 
• 1039803-54-7 (5-bromo-pyridin-2-yl)-(4-fluoro-benzyl)-amine 

Relevant articles and documents

Isoxazole-containing pyridopyrimidinone compound as well as preparation method and application thereof

The invention relates to an isoxazole-containing pyridinopyrimidinone compound as well as a preparation method and application thereof. The compound disclosed by the invention has a structure shown as a formula (I), has excellent insecticidal activity on sogatella furcifera, brown planthopper and the like, and can be used for medicines or agents for preventing and treating hemiptera pests such as rice planthoppers and aphids. The structure and the preparation process are simple, and the production cost is low.

Dithioacetal-containing pyridopyrimidone derivative as well as preparation and application thereof

The invention relates to a dithioacetal-containing pyridopyrimidone derivative as well as preparation and application thereof. The compound disclosed by the invention has a structure as shown in a formula (I) in the specification, has excellent insecticidal activity on sogatella furcifera, broad bean aphids and the like, and has a relatively good prevention and treatment effect on potato Y viruses at the same time. The compound can be used for preventing and treating hemiptera pests such as rice planthoppers and aphids, and also can be used for preventing and treating plant viruses such as potato Y viruses. The structure and the preparation process are simple, and the production cost is low.

Co(II) PCP Pincer Complexes as Catalysts for the Alkylation of Aromatic Amines with Primary Alcohols

Efficient alkylations of amines by alcohols catalyzed by well-defined Co(II) complexes are described that are stabilized by a PCP ligand (N,N′-bis(diisopropylphosphino)-N,N′-dimethyl-1,3-diaminobenzene) based on the 1,3-diaminobenzene scaffold. This reaction is an environmentally benign process implementing inexpensive, earth-abundant nonprecious metal catalysts and is based on the acceptorless alcohol dehydrogenation concept. A range of primary alcohols and aromatic amines were efficiently converted into mono-N-alkylated amines in good to excellent isolated yields.

Air Stable Iron(II) PNP Pincer Complexes as Efficient Catalysts for the Selective Alkylation of Amines with Alcohols

A series of well-defined iron(II) complexes of the types [Fe(PNP)Br2] and [Fe(PNP)(CO)Br2] with PNP pincer ligands based on triazine and pyridine backbones were prepared and fully characterized. These complexes were tested as catalysts for the alkylation of amines by alcohols. The high-spin complexes [Fe(PNP)Br2] are catalytically inactive. The low-spin complexes [Fe(PNP)(CO)Br2] bearing a carbonyl co-ligand efficiently and selectively convert primary alcohols and aromatic and benzylic amines selectively into mono-N-alkylated amines in good to excellent isolated yields. A mechanistic proposal is given. (Figure presented.).

A one-pot parallel reductive amination of aldehydes with heteroaromatic amines

A parallel reductive amination of heteroaromatic amines has been performed using a combination of ZnCl2-TMSOAc (activating agents) and NaBH(OAc)3 (reducing agent). A library of diverse secondary amines was easily prepared on a 50-300 mg scale.

A mild method for the regioselective bromination of 2-aminopyridines

An efficient and regioselective bromination of 2-aminopyridines was developed. The environmental friendly bromination occurs under mild and clean conditions using readily available 1-butylpyridinium bromide as the bromine source and hydrogen peroxide as the green oxidant.

A metal-free tandem demethylenation/C(sp2)-H cycloamination process of N -Benzyl-2-aminopyridines via C-C and C-N bond cleavage

A mild, metal-free synthesis of pyrido[1,2-a]benzimidazoles starting with N-benzyl-2-aminopyridines, which employs PhI(OPiv)2 as a stoichiometric oxidant, has been developed. The process is initiated by an unusual PhI(OPiv)2-mediated ipso SEAr reaction, followed by solvent-assisted C-C and C-N bond cleavage.

Research on antibacterial and antifungal agents. XI. Synthesis and antimicrobial activity of N-heteroaryl benzylamines and their schiff bases

The synthesis and antimicrobial activity of new N-heteroaryl benzylamines and their Schiff bases are reported. Antifungal data were compared with those obtained with miconazole, ketoconazole, enilconazole and imazalil sulfate, which showed that some of the tested compounds possessed moderate activity against strains of Candida albicans, Candida Sp and good activity against isolates of plant pathogenic fungi. In contrast the synthesized compounds showed poor antibacterial activity, except for 3j which exhibited abetter activity than nalidixic acid used as positive control. The results obtained are discussed on the basis of structure-activity relationships.