169247-46-5

Usage

Uses

Used in Pharmaceutical Industry:
2-(benzyloxy)-5-brom-1-trifluoromethylbenzene is used as a synthetic intermediate for the development of pharmaceutical compounds. Its unique structure allows for the creation of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 2-(benzyloxy)-5-brom-1-trifluoromethylbenzene serves as a precursor in the synthesis of agrochemicals, such as pesticides and herbicides. Its incorporation into these products can enhance their effectiveness in controlling pests and weeds.
It is crucial to handle 2-(benzyloxy)-5-brom-1-trifluoromethylbenzene with care due to its potential health and environmental hazards. Proper safety measures should be implemented during its production, storage, and use to minimize risks.

InChI:InChI=1/C14H10BrF3O/c15-11-6-7-13(12(8-11)14(16,17)18)19-9-10-4-2-1-3-5-10/h1-8H,9H2

Upstream product

• 50824-04-9 4-bromo-2-(trifluoromethyl)phenol 
• 100-44-7 benzyl chloride 
• 444-30-4 2-(trifluoromethyl)phenol 
• 100-39-0 benzyl bromide 

Downstream Products

• 1257078-54-8 2-(4-(benzyloxy)-3-(trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 1268862-88-9 1-(4-benzyloxy-3-trifluoromethyl-phenyl)-2-bromo-ethanone 
• 1044067-54-0 1-(4-benzyloxy-3-trifluoromethylphenyl)ethanone 
• 839694-28-9 (E)-3-(4-Benzyloxy-3-trifluoromethyl-phenyl)-acrylic acid methyl ester 
• 839694-32-5 2-bromo-4-(3-hydroxypropyl)-6-(trifluoromethyl)phenol 
• 477980-90-8 4-(benzyloxy)-3-(trifluoromethyl)benzaldehyde 
• 839694-50-7 3-(4-hydroxy-3-trifluoromethyl-phenyl)-propionic acid methyl ester 
• 839694-27-8 4-(3-hydroxypropyl)-2-(trifluoromethyl)phenol 
• 839694-30-3 4-phenylmethoxy-3-(trifluoromethyl)benzonitrile 

Relevant academic research and scientific papers

Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite Plasmodium falciparum and Optimization Efforts

A novel diazaspiro[3.4]octane series was identified from a Plasmodium falciparum whole-cell high-throughput screening campaign. Hits displayed activity against multiple stages of the parasite lifecycle, which together with a novel sp3-rich scaffold provided an attractive starting point for a hit-to-lead medicinal chemistry optimization and biological profiling program. Structure-activity-relationship studies led to the identification of compounds that showed low nanomolar asexual blood-stage activity (50 nM) together with strong gametocyte sterilizing properties that translated to transmission-blocking activity in the standard membrane feeding assay. Mechanistic studies through resistance selection with one of the analogues followed by whole-genome sequencing implicated the P. falciparum cyclic amine resistance locus in the mode of resistance.

A novel chiral surfactant-type metallomicellar catalyst for asymmetric Michael addition in water

A series of Schiff-based ligands consisting of both tertiary amines and lipophilic groups were designed and synthesized. Using these ligands, a new chiral surfactant-type metallomicellar catalyst was developed in water, and this was identified by SEM/TEM analyses. These metallomicelles can be empolyed in asymmetric Michael addition reactions in water, delivering the corresponding adducts with excellent yields and enantioselectivities.

P-Hydroxyphenacyl photoremovable protecting groups Robust photochemistry despite substituent diversity

A broadly based investigation of the effects of a diverse array of substituents on the photochemical rearrangement of p-hydroxyphenacyl esters has demonstrated that common substituents such as F, MeO, CN, CO2R, CONH2, and CH3 have little effect on the rate and quantum efficiencies for the photo-Favorskii rearrangement and the release of the acid leaving group or on the lifetimes of the reactive triplet state. A decrease in the quantum yields across all substituents was observed for the release and rearrangement when the photolyses were carried out in buffered aqueous media at pHs that exceeded the ground-state pKa of the chromophore where the conjugate base is the predominant form. Otherwise, substituents have only a very modest effect on the photoreaction of these robust chromophores.

PYRIMIDINE INHIBITORS OF KINASE ACTIVITY

The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts or solvates thereof, wherein G1, R2, R3, R4, R5, n, p, q, Ar1, and Ar2 are defined in the description. The present invention relates also to methods of making said compounds, and compositions comprising said compounds which are useful for inhibiting kinases such as IGF-IR.

Competing pathways in the photo-Favorskii rearrangement and release of esters: Studies on fluorinated p-hydroxyphenacyl-caged GABA and glutamate phototriggers

(Chemical Equation Presented) Three new trifluoromethylated p-hydroxyphenacyl (pHP)-caged γ-aminobutyric acid (GABA) and glutamate (Glu) derivatives have been examined for their efficacy as photoremovable protecting groups in aqueous solution. Through the

Synthesis of chroman derivatives by the ring expansion reaction of spirodienones, and an assessment of their plant growth inhibition

Lewis acid-promoted 1,2-shift rearrangement reactions of the spirodienones, generated by the anodic oxidation of phenol derivatives, provided corresponding chromans. In addition to steric repulsion, electron-donating or withdrawing characteristics of the

Dihaloprene compound, insecticide/acaricide containing said dihalopropene compound as active ingredient, and intermediate compound for use in production of said dihalopropene compound

There is disclosed a dihalopropene compound of the formula I: STR1 wherein l is an integer of 1 to 5; m is an integer of 1 to 4; R1 's and R2 's are the same or different and are independently halogen or various other groups; D is oxygen; X's are the same or different and are independently chlorine or bromine; Y is oxygen; Z, P and Q are the same or different and are independently nitrogen or CH, provided that P and Q are not simultaneously nitrogen, and when Y is sulfur, Z is CH. Also disclosed is an insecticide/acaricide comprising the dihalopropene compound as an active ingredient. The dihalopropene compound exhibits excellent insecticidal/acaricidal action. Further disclosed is an intermediate compound for use in the production of the dihalopropene compound.