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Enantioselective Synthesis of Allyl- and Propargylamines via Nucleophilic 1,2-Addition to Chiral Aldimines
Enders, Dieter,Schankat, Juergen
, p. 402 - 406 (2007/10/02)
The asymmetric synthesis of allylamines and propargylamines 5 in high enantiomeric purity (e.e >/= 97percent) is described.Key step is the 1,2-addition of organocerium reagents to chiral α,β-unsaturated aldimines 3 to produce secondary amines 4.The chiral
