169302-18-5Relevant academic research and scientific papers
Highly diastereo- and enantio-selective epoxidation of secondary allylic alcohols catalyzed by styrene monooxygenase
Lin, Hui,Liu, Yan,Wu, Zhong-Liu
, p. 2610 - 2612 (2011/04/26)
Enantiomerically enriched glycidol derivatives with contiguous stereogenic centers were obtained in a highly diastereo- and enantio-selective epoxidation catalyzed with the styrene monooxygenase StyAB2.
Total syntheses of kurasoins A and B, novel protein farnesyltransferase inhibitors, and absolute structures of kurasoins A and B
Hirose, Tomoyasu,Sunazuka, Toshiaki,Zhi-Ming, Tian,Handa, Masaki,Uchida, Ryuji,Shiomi, Kazuro,Harigaya, Yoshihiro,Omura, Satoshi
, p. 777 - 784 (2007/10/03)
Asymmetric total syntheses of kurasoins A (1) and B (2), recently discovered protein farnesyltransferase (PFTase) inhibitors, have been achieved in seven steps from 2-(4-hydroxyphenyl)ethanol via the stereospecific alkylation of the chiral epoxide ((-)-7) and in four steps from phenylacetaldehyde via the coupling reaction of the chiral epoxide ((-)- 13) with indole, respectively. The synthesis defined the (3S) absolute configuration of 1 and 2. The stereochemistry of the hydroxy group is important for eliciting PFTase inhibition.
Synthesis of All Four Possible Stereoisomers of 1-Phenyl-2,3-butanediol and Both Enantiomers of 3-Hydroxy-4-phenyl-2-butanone to Determine the Absolute Configuration of the Natural Constituents
Awano, Ken-ichi,Yanai, Tetsuya,Watanabe, Ichiro,Takagi, Yoshikazu,Kitahara, Takeshi,Mori, Kenji
, p. 1251 - 1254 (2007/10/02)
Enantioselective syntheses of all the possible stereoisomers of 1-phenyl-2,3-butanediol (erythro isomer 1 and threo isomer 2) and of 3-hydroxy-4-phenyl-2-butanone 3, the odor components of wisteria flowers, was accomplished via Sharpless asymmetric epoxyd
