16931-35-4

Basic information

• Product Name: 1H-Benzimidazole,4-chloro-(9CI)
• Synonyms: 1H-Benzimidazole,4-chloro-(9CI);4-Chloro-1H-benzimidazole;4-Chlorobenzimidazole;4-chloro-1H-1,3-benzodiazole;7-chloro-1H-benzo[d]iMidazole;7-chloro-1H-Benzimidazole;7-Chloro-1H-benzoimidazole
• CAS NO: 16931-35-4
• Molecular Formula: C14H15N3O3S
• Molecular Weight: 305.357
• Product Categories: BENZIMIDAZOLE
• Mol File: 16931-35-4.mol
• Article Data: 7

Chemical Properties

• Melting Point: 170-171℃
• Boiling Point: 393.8 °C at 760 mmHg
• Flash Point: 224.2 °C
• Appearance: /
• Density: 1.425
• Vapor Pressure: 4.7E-06mmHg at 25°C
• Refractive Index: 1.703
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1H-Benzimidazole,4-chloro-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Benzimidazole,4-chloro-(9CI)(16931-35-4)
• EPA Substance Registry System: 1H-Benzimidazole,4-chloro-(9CI)(16931-35-4)

Safety Data

• Hazardous Substances Data: 16931-35-4(Hazardous Substances Data)

Usage

General Description

1H-Benzimidazole, 4-chloro-(9CI) is a chemical compound with the molecular formula C7H5ClN2. It is a chlorinated derivative of benzimidazole, which is a heterocyclic aromatic organic compound. This chemical is often used in the pharmaceutical industry as an intermediate for the synthesis of various drugs and pharmaceuticals. It has been studied for its potential pharmacological activities, including as an anti-inflammatory and anti-cancer agent. Additionally, 1H-Benzimidazole, 4-chloro-(9CI) has also been investigated for its potential use in the development of new materials and substances for various industrial applications. Overall, this chemical compound has potential for various applications in the fields of medicine, material science, and industry.

InChI:InChI=1/C7H5ClN2/c8-5-2-1-3-6-7(5)10-4-9-6/h1-4H,(H,9,10)

Upstream product

• 119072-55-8 tert-butylisonitrile 
• 21745-41-5 2,3-diaminochlorobenzene 
• 122-51-0 orthoformic acid triethyl ester 
• 64-17-5 ethanol 
• 64-18-6 formic acid 
• 59483-54-4 3-chloro-2-nitro-aniline 
• 602-02-8 2,3-dinitrochlorobenzene 

Downstream Products

• 1313803-00-7 3-(3-(4-(4-(trifluoromethyl)phenyl)-1H-benzo[d]imidazol-1-yl)benzylamino)benzoic acid 
• 1610566-43-2 C₂₁H₁₃F₃N₂O 

Relevant articles and documents

BICYCLIC HETEROARYL DERIVATIVES AS ECTONUCLEOTIDE PYROPHOSPHATASE PHOSPHODIESTERASE 1 INHIBITORS

The present disclosure provides certain bicyclic heteroaryl compounds that inhibit ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) enzymatic activity and are therefore useful for the treatment of diseases and conditions modulated at least in part by ENPP1. In some embodiments, the bicyclic heteroaryl compounds includes those of Formula (I). Also provided herein are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

Microwave use of amidine compounds in the aqueous phase benzoate synthesis of benzimidazole compounds method

The invention discloses a microwave the use of amidine compounds in the aqueous phase benzoate synthesis of benzimidazole compounds, in the aqueous phase under microwave conditions adding benzoic amidine compound under alkaline condition [...] into benzimidazole reaction, invention an environment-friendly, the operation is simple, cheap and safe, efficient process for preparing benzimidazole method. Compared with the prior art, this method not only can be applied to a large number of functional groups, the productive rate is high, few by-products, and the operation is simple, safe, low cost, environmental protection; .

Ultrasound promoted expeditious, catalyst-free and solvent-free approach for the synthesis of N,N′-diarylsubstituted formamidines at room temperature

An effortless and efficient protocol was developed for the synthesis of N,N′-diarylsubstituted formamidines under environment-friendly conditions. Ultrasonic energy was employed to obtain the desired products in excellent yields with high purity under solvent-free and catalyst-free conditions. Products were purified by the crystallization technique to avoid excess utilization of organic solvents.