169332-60-9

Basic information

• Product Name: AC-DEVD-CHO
• Synonyms: N-ACETYL-L-ALPHA-ASPARTYL-L-ALPHA-GLUTAMYL-N-(2-CARBOXY-1-FORMYLETHYL)-L VALINAMIDE;N-AC-ASP-GLU-VAL-ASP-CHO;N-ACETYL-ASP-GLU-VAL-ASP-AL;N-ACETYL-ASP-GLU-VAL-ASP-CHO (ALDEHYDE);ACETYL-DEVD-ALDEHYDE;ACETYL-L-ASPARTYL-L-GLUTAMYL-L-VALYL-L-ASPART-1-AL;ACETYL-ASP-GLU-VAL-ASP-ALDEHYDE;AC-DEVD-CHO
• CAS NO: 169332-60-9
• Molecular Formula: C20H30N4O11
• Molecular Weight: 502.47
• Product Categories: Caspase 10;Caspase 3;Caspase 7;Caspase 8;Caspase Inhibitors;Caspase Inhibitors and Substrates;Peptides and Proteins;Peptides for Cell Biology;Protease Inhibitor Specificity Index;Protease Inhibitors;A to C;A-AM;Aldehydes;and Substrates;Apoptosis and Cell Cycle;Apoptosis Enzymes;Application Index;Bioactive Small Molecules;Biochemicals and Reagents;Building Blocks;C13-C60;Carbonyl Compounds;Caspases;Cell Biology;Cell Signaling and Neuroscience;Cell Signaling Enzymes;Chemical Synthesis;Enzyme Inhibitors;Enzyme Inhibitors by Enzyme;Enzymes;Inhibitors;Organic Building Blocks;Pepetides;peptides
• Mol File: 169332-60-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 1021.1°Cat760mmHg
• Flash Point: 571.3°C
• Appearance: white/powder
• Density: 1.374g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.535
• Storage Temp.: −20°C
• Solubility: H2O: 1 mg/mL
• PKA: 4.19±0.10(Predicted)
• Sensitive: Moisture Sensitive
• CAS DataBase Reference: AC-DEVD-CHO(CAS DataBase Reference)
• NIST Chemistry Reference: AC-DEVD-CHO(169332-60-9)
• EPA Substance Registry System: AC-DEVD-CHO(169332-60-9)

Safety Data

• WGK Germany: 3
• RTECS: EK7643000
• Hazardous Substances Data: 169332-60-9(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 169332-60-9 differently. You can refer to the following data:
1. Reversible inhibitor of interleukin-1beta converting enzyme (ICE); also inhibits caspase-3 cleavage of poly(ADP-ribose) polymerase
2. N-Acetyl-Asp-Glu-Val-Asp-al has been used as a caspase inhibitor in muscle samples, smooth muscle cells and Jurkat T-cells.

Definition

ChEBI: A tetrapeptide consisting of two L-aspartic acid residues, an L-glutamyl residue and an L-valine residue with an acetyl group at the N-terminal and with the C-terminal carboxy group reduced to an aldehyde. It is an inhibitor of caspase-3/7.

General Description

N-Acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO) is a tetrapeptide with N-terminal acetylation and C-terminal aldehyde conjugation.

Biochem/physiol Actions

N-Acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO) aids in the recovery of stunned myocardium by its caspase inhibition functionality.

InChI:InChI=1/C20H30N4O11/c1-9(2)17(20(35)22-11(8-25)6-15(29)30)24-18(33)12(4-5-14(27)28)23-19(34)13(7-16(31)32)21-10(3)26/h8-9,11-13,17H,4-7H2,1-3H3,(H,21,26)(H,22,35)(H,23,34)(H,24,33)(H,27,28)(H,29,30)(H,31,32)/t11-,12-,13-,17-/m0/s1

Upstream product

• 7732-18-5 water 

Relevant articles and documents

PEPTIDYL DERIVATIVES AS INHIBITORS OF PRO-APOPTOTIC CYSTEINE PROTEINASES

Compounds having the formula I:R 1 COAA. sup.1 AA. sup.2 AA 3 NHYare inhibitors of apopain, an enzyme involved in the process of apoptosis. These compounds are useful as research tools as well as in the treatment of any condition in which reduced apoptosis would be beneficial, including immune deficiency syndromes (including AIDS), type I diabetes, pathogenic infections, cardiovascular and neurological injury, alopecia, aging, Parkinson's disease and Alzheimer's disease.