16934-13-7

Upstream product

• 24180-12-9 3-amino-2-methyl-3-phenyl-propionic acid 
• 100-52-7 benzaldehyde 
• 17599-61-0 N-benzylidene-1,1,1-trimethylsilanamine 

Downstream Products

• 144381-73-7 (2S,3R)-2-Methyl-3-phenyl-3-(toluene-4-sulfonylamino)-propionic acid methyl ester 
• 24180-12-9 (2RS,3SR)-3-amino-2-methyl-3-phenylpropionic acid 

Relevant academic research and scientific papers

Diastereoselective Hydrogenation of Methyl 2-acrylate Catalyzed by Ru(II) or Rh(I) Complexes

The title compound was prepared and hydrogenated by using a Ru(II)- or Rh(I)-phosphine catalyst precursor with excellent anti-selectivity, the results indicating that a ligating group, NHCO2Me, may direct the addition of hydrogen to an olefinic diastereof

N-Trimethylsilyl Imines: Applications to the Synthesis of β-Lactams

Ester enolates and N-trimethylsilyl imines react to afford N-protio-β-lactams.The stereochemical course of the reaction depends on the ester enolate geometry.Therefore (E)-enolates give mainly cis β-lactams while (Z)-enolates give nearly equal mixtures of cis and trans β-lactams.The use of ethyl β-hydroxybutyrate as the ester component allows the preparation of β-lactams of potential use in carbapenem synthesis.The differences in the behavior of N-trimethylsilyl and N-aryl imines in ester-imine condensations are also discussed.