1694-06-0Relevant articles and documents
Synthesis method of P-toluenesulfonyl semicarbazide foaming agent
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Paragraph 0058-0118, (2020/01/25)
The invention discloses a synthesis method of a p-toluenesulfonyl semicarbazide foaming agent. The synthesis method comprises the following steps: S1, reducing p-toluenesulfonyl chloride into a p-toluenesulfinate in the presence of an inorganic alkali by using p-toluenesulfonyl chloride as an initial raw material, sodium sulfite as a reducing agent and water as a solvent to obtain a p-toluenesulfinate aqueous solution; and S2, adding azodicarbonamide into the p-toluenesulfinate aqueous solution obtained in the step S1 for a reaction, stopping the reaction when no gas is released, and carryingout cooling, filtering, water washing and drying to obtain a target product, namely the p-toluenesulfonyl semicarbazide, wherein the reaction temperature in the step S2 is 70-90 DEG C, preferably, thereaction temperature in the step S2 is 78-82 DEG C. The synthesis method disclosed by the invention is safe and environmentally friendly, is high in yield, and is simple to operate; the raw materialsare convenient and easy to obtain and are low in cost; and thus the synthesis method is a synthesis route suitable for industrial production.
Synthesis method of p-toluenesulfonylurea
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Paragraph 0024-0025; 0028-0029; 0032-0033; 0036-0037, (2020/10/20)
The invention relates to a synthesis method of p-toluenesulfonylurea. The synthesis method comprises the following steps: dissolving p-toluenesulfonamide and sodium cyanate in a mixed solution of water and ethanol to react, filtering after the reaction is finished, acidifying the filtered mother solution, and filtering again, thereby finally obtaining p-toluenesulfonylurea. According to the method, no by-product or ammonia gas is generated, the yield of the target product reaches 90% or above, the purity is larger than 99%, the process is simple, operation steps are simple and convenient, theoperation environment is non-toxic and free of pollution, no waste gas is generated, production energy consumption is low, the yield is high, and the method has very high popularization value.
Preparation method for high-purity gliclazide intermediate namely p-toluenesulfonylurea
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Paragraph 0028-0031; 0036-0047, (2019/11/12)
The invention discloses a simple and convenient preparation method for p-toluenesulfonylurea. The preparation method comprises the following reaction steps: according to a reaction flow as shown in aformula 3 which is described in the specification, filling a reaction container with nitrogen gas to replace air in the reaction container, then adding an organic solvent and p-toluenesulfonyl isocyanate, then charging ammonia gas, carrying out a reaction at a low temperature under stirring so as to generate a crude p-toluenesulfonylurea product, then carrying out filtering, adding acetonitrile/water for refluxing, carrying out programmed cooling (10 DEG C/h), and carrying out centrifuging and drying so as to obtain a white crystal, namely, the p-toluenesulfonylurea. The preparation method provided by the invention prepares the p-toluenesulfonylurea by ammonolysis of the p-toluenesulfonyl isocyanate with the ammonia gas in toluene and can reach a yield up to 96.3%; and a product has a purity of 99.9% or more, is a white crystalline solid and is free of impurities. The preparation method provided by the invention has the following advantages: operation is simple and convenient; conditions are mild; post-treatment is easy; and a product has high purity and high yield, is a white crystal and facilitates storage.
CARBONIC ANHYDRASE INHIBITORS. 9. INHIBITORS WITH MODIFIED SULFONAMIDO GROUPS AND THEIR INTERACTION WITH THE ZINC ENZYME
Supuran, Claudiu T.,Banciu, Mircea D.
, p. 1345 - 1354 (2007/10/03)
A number of 20 compounds, containing modified sulfonamido groups were prepared and tested as carbonic anhydrase inhibitors on the bovine enzyme. Novel classes of inhibitors were evidenced, and a new mode of binding for bidentate inhibitors was proposed, both for the native and Co(II) substituted enzyme.
SYNTHESIS AND PROPERTIES OF ISOMERIC N-ARYLSULFONYL-N-NITROGUANIDINES
Dobonravov, A. N.,Dubina, V. L.,Svistun, N. V.
, p. 480 - 483 (2007/10/02)
Methods were developed for the synthesis of isomeric N-tosyl-N-nitroguanidines with the nitro group at various nitrogen atoms.Their reactions with diazomethane, acetylacetone, and primary amines and their alkaline hydrolysis were studied.A new method is developed for the production of N1-tosyl-N2-alkylguanidines.
