16948-63-3

Usage

Classification

Organic compound

Functional Groups

Amino group ($-NH2$)
Sulfonamide group ($-SO2NH2$)

Substituents

Two chlorine atoms (Cl) attached to the benzene ring

Application

Pharmaceutical Intermediate: Used in the synthesis of various drugs, particularly those with antibacterial and antimicrobial properties.
Agricultural Use: Component in pesticides and herbicides.
Scientific Research: Chemical reagent and in the development of new pharmaceutical compounds.

InChI:InChI=1/C6H6Cl2N2O2S/c7-3-1-5(9)6(2-4(3)8)13(10,11)12/h1-2H,9H2,(H2,10,11,12)

Upstream product

• 95-76-1 m,p-dichloroaniline 
• 36110-12-0 2-amino-4,5-dichlorobenzenesulfonyl chloride 

Downstream Products

• 446-62-8 (+/-)-6,7-dichloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide 
• 93534-14-6 6,7-dichloro-3-phenoxymethyl-2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide 
• 1349036-74-3 6,7-dichloro-3-(2-chlorophenyl)-4H-1,2,4-benzothiadiazine-1,1-dioxide 
• 101063-94-9 3-(6,7-Dichloro-1,1-dioxo-1,4-dihydro-1λ⁶-benzo[1,2,4]thiadiazin-3-yl)-propionic acid 
• 101064-02-2 4-(6,7-Dichloro-1,1-dioxo-1,4-dihydro-1λ⁶-benzo[1,2,4]thiadiazin-3-yl)-butyric acid 
• 93534-11-3 6,7-dichloro-3-phenylsulfanylmethyl-2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide 
• 95696-40-5 6,7-dichloro-3-dicyclohexylmethyl-2⁽⁴⁾H-benzo[1,2,4]thiadiazine 1,1-dioxide 
• 95486-90-1 6,7-dichloro-3-(cyclohexyl-phenyl-methyl)-2⁽⁴⁾H-benzo[1,2,4]thiadiazine 1,1-dioxide 
• 97074-12-9 3-benzhydryl-6,7-dichloro-2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide 
• 359-86-4 6,7-Dichlor-3,4-dihydro-1,2,4-benzothiadiazin-1,1-dioxid 
• 66126-88-3 6,7-dichloro-3-chloromethyl-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide 

Relevant academic research and scientific papers

Hydroxylated analogues of ATP-sensitive potassium channel openers belonging to the group of 6- and/or 7-substituted 3-Isopropylamino-4H-1,2,4- benzothiadiazine 1,1-dioxides: Toward an improvement in sulfonylurea receptor 1 selectivity and metabolism stabi

Diversely substituted 3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides are known to be potent KATP channel openers, with several drugs being selective for the SUR1/Kir6.2 channel subtype. This work examined the biological activity, tissu

3-Alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as ATP-sensitive potassium channel openers: Effect of 6,7-disubstitution on potency and tissue selectivity

A series of 6,7-disubstituted 4H-1,2,4-benzothiadiazine 1,1-dioxides bearing a short alkylamino side chain in the 3-position were synthesized. These compounds were tested on rat pancreatic islets and on rat aorta rings. In vitro data indicated that in mos