36110-12-0Relevant academic research and scientific papers
3-Alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as ATP-sensitive potassium channel openers: Effect of 6,7-disubstitution on potency and tissue selectivity
De Tullio, Pascal,Boverie, Stéphane,Becker, Bénédicte,Antoine, Marie-Hélène,Nguyen, Quynh-Anh,Francotte, Pierre,Counerotte, Stéphane,Sebille, Sophie,Pirotte, Bernard,Lebrun, Philippe
, p. 4990 - 5000 (2005)
A series of 6,7-disubstituted 4H-1,2,4-benzothiadiazine 1,1-dioxides bearing a short alkylamino side chain in the 3-position were synthesized. These compounds were tested on rat pancreatic islets and on rat aorta rings. In vitro data indicated that in mos
Structural insights of SmKDAC8 inhibitors: Targeting Schistosoma epigenetics through a combined structure-based 3D QSAR, in vitro and synthesis strategy
Ballante, Flavio,Reddy, D. Rajasekhar,Zhou, Nancy J.,Marshall, Garland R.
, p. 2105 - 2132 (2017/03/23)
A predictive structure-based 3D QSAR (COMBINEr 2.0) model of the Schistosoma mansoni lysine deacetylase 8 enzyme (SmKDAC8) was developed, validated and used to perform virtual screening (VS) of the NCI Diversity Set V database (1593 compounds). Three exte
1,2,4-Benzothiadiazine-1,1-dioxide derivatives as Ionotropic glutamate receptor ligands: Synthesis and structure-activity relationships
Varano, Flavia,Catarzi, Daniela,Colotta, Vittoria,Squarcialupi, Lucia,Matucci, Rosanna
, p. 777 - 785 (2015/04/22)
Ionotropic glutamate receptor (iGluR) modulators, specially AMPA receptor antagonists, are potential tools for numerous therapeutic applications in neurological disorders, including Alzheimer's and Parkinson's diseases, amyotrophic lateral sclerosis, epil
