16951-27-2 Usage
General Description
"(2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDIN-4-YL)ACETIC ACID" is a chemical compound with the molecular formula C7H8N2O4. It is a derivative of pyrimidine and has a tetrahydropyrimidine structure. (2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDIN-4-YL)ACETIC ACID is a carboxylic acid and can act as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. It has potential applications in the field of medicinal chemistry and drug discovery. The specific properties and uses of this compound may vary depending on its formulation and purity.
Check Digit Verification of cas no
The CAS Registry Mumber 16951-27-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,9,5 and 1 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 16951-27:
(7*1)+(6*6)+(5*9)+(4*5)+(3*1)+(2*2)+(1*7)=122
122 % 10 = 2
So 16951-27-2 is a valid CAS Registry Number.
16951-27-2Relevant articles and documents
Thioxo-dihydroquinazolin-one Compounds as Novel Inhibitors of Myeloperoxidase
Li, Yang,Ganesh, Thota,Diebold, Becky A,Zhu, Yerun,McCoy, James W,Smith, Susan M. E,Sun, Aiming,Lambeth, J. David
, p. 1047 - 1052 (2015/10/20)
Myeloperoxidase (MPO) is a key antimicrobial enzyme, playing a normal role in host defense, but also contributing to inflammatory conditions including neuroinflammatory diseases such as Parkinsons and Alzheimers. We synthesized and characterized more than 50 quinazolin-4(1H)-one derivatives and showed that this class of compounds inhibits MPO with IC50 values as low as 100 nM. Representative compounds showed partially reversible inhibition that was competitive with respect to Amplex Red substrate and did not result in the accumulation of MPO Compound II. Members of this group show promise for therapeutic development for the treatment of diseases in which inflammation plays a pathogenic role.
