16958-47-7Relevant articles and documents
Preparation method of alkyl phosphorylated substances
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Paragraph 0023, (2019/10/04)
The invention discloses a preparation method of alkyl phosphorylated substances. According to the invention, alkyl carboxylic acid is used as a starting material, and raw materials are easy to obtain and are various in types. Products prepared by the method disclosed by the invention are various in types and wide in application; and a part of the products can be prepared into important phosphorus ligands and drug key intermediates through simple reduction. In addition, use of high-toxicity phosphine reagents is avoided in the method, the reaction conditions are mild, operation is simple, the yield of the target product is high, pollution is small, and the reaction operation and post-treatment processes are simple, so that the method is suitable for industrial production.
REACTIONS OF CYCLOALKYL CHLORIDES AND BROMIDES WITH DIPHENYLPHOSPHIDE IONS IN LIQUID AMMONIA
Nazareno, Monica A.,Palacios, Sara M.,Rossi, Roberto A.
, p. 421 - 426 (2007/10/02)
The reactions of cycloalkyl (butyl, pentyl, hexyl and heptyl) chlorides and bromides with diphenylphosphide ions were studied in liquid ammonia.Cyclobutyl chloride was unreactive, whereas the bromide reacted giving the substitution product cyclobutyldiphenylphosphine (isolated as the oxide) in good yields; this reaction was catalysed by light and partially inhibited by p-dinitrobenzene (p-DNB).Cyclopentyl, cyclohexyl and cycloheptyl chlorides did not react in the dark, but the substitution products were formed under irradiation, and these reactions were partially by p-DNB.The bromides reacted in the dark or under irradiation, and these reactions were inhibited by p-DNB.It can be then concluded that the reactivity of cycloalkyl halides depends on the ring size and the nucleofugal group.In addition, as the overall reactivity decreases, there is an increase in electron transfer reactions.
