16958-94-4Relevant academic research and scientific papers
Aryloxymethyl derivatives of nitrogenous heterocyclic methanols and ethers thereof
-
, (2008/06/13)
Novel heterocyclicmethanols are disclosed having the formula: STR1 wherein Z is pyrrolidinyl, piperidinyl, homopiperidinyl or pyridinyl; R1 is hydrogen, loweralkyl or carbethoxymethyl; R2 is hydrogen, loweralkyl, cycloalkyl, phenyl or phenyl-loweralkyl; R3 is 1 or 2-naphthalenyl, 2,3-dihydroinden-4 or 5-yl, phenyl or phenyl substituted by loweralkyl, loweralkoxy, halogen, trifluoromethyl, phenyl, methylenedioxy, nitro, amino, loweralkylamino, diloweralkylamino, loweracylamino; the 1-position of 2-pyrrolidinyl, 2-piperidinyl or 2-homopiperidinyl may be substituted by an R4 loweralkyl group, or R1 may form methylene or --CH2 -C(O)-bridges with R4 ; the pharmaceutically acceptable salts and diastereomers thereof, which compounds have antiarrhythmic and/or hypotensive activity in animals.
Process for making alkali metal aryloxides
-
, (2008/06/13)
The reaction of alkali metal with aromatic hydroxy compounds is promoted by inclusion of an alcohol in the reaction mixture. The alkali metal aryloxide formed can be reacted with phosphonitrilic chloride polymers to make polyaryloxyphosphazenes.
HETEROCYCLIC COMPOUNDS
-
, (2008/06/13)
Compounds of Formula I are described STR1 in which X and Y are independently--NH--,--O--or--S--; Z may be a pyrimidine, triazine, triazole, thiazole, thiadiazole ring. The methods of preparation are described. The compounds are useful as antipeptic ulcer agents.
