169611-40-9Relevant academic research and scientific papers
Biosynthesis of Valine and Isoleucine: Synthesis and Biological Activity of (2S)-&α-Acetolactic Acid (2-Hydroxy-2-methyl-3-oxobutanoic Acid), and (2R)- and (2S)-&α-Acetohydroxybutyric Acid (2-Ethyl-2-hydroxy-3-oxobutanoic Acid)
Armstrong, Frank B.,Lipscomb, Elizabeth L.,Crout, David H. G.,Mitchell, Michael B.,Prakash, Shimoga R.
, p. 1197 - 1202 (2007/10/02)
Stereoisomers of the two substrates for the enzyme reductoisomerase of the valine-isoleucine pathway of biosynthesis have been synthesised in optically pure form.These compounds are (2S)-α-acetolactate (2-hydroxy-2-methyl-3-oxobutanoate) and (2R)- and (2S)-α-acetohydroxybutyrate (2-ethyl-2-hydroxy-3-oxobutanoate).The synthesis of (2S)-α-acetolactate represents the first synthesis in optically pure form of the substrate of the enzyme in the valine pathway.Only the (2S)-isomers of these compounds acted as substrates for the reductoisomerase of Salmonella typhimurium.
