169614-01-1

Basic information

• Product Name: Acetic acid (S)-1-chloromethyl-2-[4-(2-cyclopropylmethoxy-ethyl)-phenoxy]-ethyl ester
• CAS NO: 169614-01-1
• Molecular Weight: 326.82
• Mol File: 169614-01-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Acetic acid (S)-1-chloromethyl-2-[4-(2-cyclopropylmethoxy-ethyl)-phenoxy]-ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid (S)-1-chloromethyl-2-[4-(2-cyclopropylmethoxy-ethyl)-phenoxy]-ethyl ester(169614-01-1)
• EPA Substance Registry System: Acetic acid (S)-1-chloromethyl-2-[4-(2-cyclopropylmethoxy-ethyl)-phenoxy]-ethyl ester(169614-01-1)

Safety Data

• Hazardous Substances Data: 169614-01-1(Hazardous Substances Data)

Upstream product

• 63659-17-6 1-[2-(cyclopropyl-methoxy)-ethyl]-4-(2,3-epoxypropoxy)-benzene 
• 108-05-4 vinyl acetate 
• 169613-99-4 1-chloro-3-<4-(2-cyclopropylmethoxy)ethyl>phenoxypropan-2-ol 

Downstream Products

• 91878-53-4 (+)-Betaxolol 

Relevant articles and documents

A chemoenzymatic route to both enantiomers of betaxolol

Evaluation of some of the possible lipase-catalyzed transformations has been done in order to prepare both enantiomers of betaxolol. Resolution of betaxolol by lipase-catalyzed hydrolysis of its bisacetylated derivatives 4 led to (-)- and (+)-enantiomers with an ee of 20 and 60%, respectively. When the resolution was performed on the chlorohydrin precursor 6 of betaxolol, (-)- and (+)-enantiomers were obtained with an ee of 91 and 75%, respectively.