169677-20-7 Usage
Uses
Used in Pharmaceutical Industry:
4-TERT-AMYLBENZENESULFONYL CHLORIDE is used as a reagent for the synthesis of pharmaceuticals, where it introduces the sulfonate group into organic molecules to enhance their properties and effectiveness as potential drugs.
Used in Agrochemical Industry:
In the agrochemical sector, 4-TERT-AMYLBENZENESULFONYL CHLORIDE is utilized as a reagent for the synthesis of agrochemicals, contributing to the development of new compounds with improved performance in agricultural applications.
Used in Dye and Pigment Production:
4-TERT-AMYLBENZENESULFONYL CHLORIDE is used as an intermediate in the production of dyes and pigments, playing a crucial role in the creation of colorants for various industries, including textiles, plastics, and printing.
Used in Manufacturing of Commercial Products:
As an important intermediate, 4-TERT-AMYLBENZENESULFONYL CHLORIDE is used in the manufacture of a variety of commercial products, where its ability to form sulfonamides and sulfonates is essential for the development of innovative and improved materials.
Check Digit Verification of cas no
The CAS Registry Mumber 169677-20-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,9,6,7 and 7 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 169677-20:
(8*1)+(7*6)+(6*9)+(5*6)+(4*7)+(3*7)+(2*2)+(1*0)=187
187 % 10 = 7
So 169677-20-7 is a valid CAS Registry Number.
InChI:InChI=1/C11H15ClO2S/c1-4-11(2,3)9-5-7-10(8-6-9)15(12,13)14/h5-8H,4H2,1-3H3
169677-20-7Relevant academic research and scientific papers
Fragment-Based Design, Synthesis, and Biological Evaluation of 1-Substituted-indole-2-carboxylic Acids as Selective Mcl-1 Inhibitors
Wang, Ziqian,Xu, Wenjie,Song, Ting,Guo, Zongwei,Liu, Lu,Fan, Yudan,Wang, Anhui,Zhang, Zhichao
, (2017/01/11)
Based on a known selective Mcl-1 inhibitor, 6-chloro-3-(3-(4-chloro-3,5-dimethylphenoxy)propyl)-1H-indole-2-carboxylic acid, we applied a fragment-based approach to obtain new molecules that extended into the p1 pocket of the BH3 groove and then exhibited binding selectivity for the Mcl-1 over the Bcl-2 protein. After we deconstructed the 1H-indole-2-carboxylic acid from the parental molecule, a benzenesulfonyl was substituted at the 1-position to adopt a geometry preferred for accessing the p1 pocket according to the binding mode of the parental molecule identified by X-ray crystallography. A linear relationship between the free energy of ligand binding (ΔG) and the count of non-hydrogen heavy atoms (HAC) was maintained during the molecular growing to occupy the p1 pocket. Finally, we not only obtained compound 12 with a 7.5-fold selectivity to Mcl-1 (Ki = 0.48 μM by fluorescence polarization) over Bcl-2 (Ki = 3.6 μM), but also provided evidence that additional occupation of the p1 pocket is more favorable for Mcl-1 than for Bcl-2 binding, and contributes more to Mcl-1 inhibition than occupation of the p2 pocket. Compound 12 exhibited a selective killing ability on Mcl-1-dependent cancer cells.
