169739-76-8Relevant academic research and scientific papers
Synthesis method of 3-amino-4-chloro-N-(3-chloro-2-methylphenyl)benzamide
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, (2016/12/22)
The invention discloses a synthesis method of 3-amino-5-chloro-N,3-dimethyl benzamide, and belongs to the organic chemical synthesis technical field. The synthesis method comprises the steps: 3-nitro-4-chlorobenzoic acid is used as a raw material, N,N'-diisopropyl carbodiimide is used as a condensing agent, 1-hydroxybenzotriazole is used as a condensation activator, firstly, 3-nitro-4-chlorobenzoic acid and N,N'-diisopropyl carbodiimide are subjected to an addition reaction, an addition product is not stable and is converted to a corresponding ester under the action of 1-hydroxybenzotriazole, then the corresponding ester is subjected to a reaction with 3-chloro-2-methylaniline to obtain 3-nitro-4-chloro-N-(3-chloro-2-methylphenyl)benzamide, next the 3-nitro-4-chloro-N-(3-chloro-2-methylphenyl)benzamide is reduced into 3-amino-4-chloro-N-(3-chloro-2-methylphenyl)benzamide under the action of zinc and sodium hydroxide. The synthesis method has the advantages of simple operation, less steps, and short production cycle, and the synthesis yield is increased significantly and is increased to 95% or more.
