169751-72-8

Basic information

• Product Name: PEG4-tert-butyl acetate
• Synonyms: PEG4-tert-butyl acetate;PEG5-tert-butyl acetate;PEG5-t-butyl acetate;HO-PEG4-CH2CO2t-Bu;Hydroxy-PEG4-t-butyl acetate;Hydroxy-PEG4-CH2CO2tBu;OH-PEG4-CH2COOH;Hydroxy-PEG4-CH2COOtBu
• CAS NO: 169751-72-8
• Molecular Formula: C₁₄H₂₈O₇
• Molecular Weight: 308.36792
• Mol File: 169751-72-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 393.1±32.0 °C(Predicted)
• Appearance: /
• Density: 1.077±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• Solubility: Soluble in Water, DMSO, DCM, DMF
• PKA: 14.36±0.10(Predicted)
• CAS DataBase Reference: PEG4-tert-butyl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: PEG4-tert-butyl acetate(169751-72-8)
• EPA Substance Registry System: PEG4-tert-butyl acetate(169751-72-8)

Safety Data

• Hazardous Substances Data: 169751-72-8(Hazardous Substances Data)

Usage

Description

Hydroxy-PEG4-CH2CO2tBu is a PEG linker containing a hydroxyl group with a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Upstream product

• 112-60-7 Tetraethylene glycol 
• 5292-43-3 bromoacetic acid tert-butyl ester 
• 169751-71-7 [2-(2-{2-[2-(tert-Butyl-dimethyl-silanyloxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-acetic acid tert-butyl ester 
• 134179-40-1 tetraethyleneglycol mono(tert-butyldimethylsilyl)ether 

Downstream Products

• 169751-73-9 tert-butyl 2-[2-[2-[2-[2-(p-tolylsulfonyloxy)ethoxy]ethoxy]ethoxy]ethoxy]acetate 

Relevant articles and documents

Protein degradation through covalent inhibitor-based PROTACs

Tremendous advancements in proteolysis targeting chimera (PROTAC) technology have been made in recent years. However, whether a covalent inhibitor-based PROTAC can be developed remains controversial. Here, we successfully developed chimeric degraders based on covalent inhibitors to degrade BTK and BLK kinases, demonstrating that covalent inhibitor-based PROTACs are viable and useful tools.

Identification and Characterization of von Hippel-Lindau-Recruiting Proteolysis Targeting Chimeras (PROTACs) of TANK-Binding Kinase 1

Proteolysis targeting chimeras (PROTACs) are bifunctional molecules that recruit an E3 ligase to a target protein to facilitate ubiquitination and subsequent degradation of that protein. While the field of targeted degraders is still relatively young, the potential for this modality to become a differentiated and therapeutic reality is strong, such that both academic and pharmaceutical institutions are now entering this interesting area of research. In this article, we describe a broadly applicable process for identifying degrader hits based on the serine/threonine kinase TANK-binding kinase 1 (TBK1) and have generalized the key structural elements associated with degradation activities. Compound 3i is a potent hit (TBK1 DC50 = 12 nM, Dmax = 96%) with excellent selectivity against a related kinase IKK?, which was further used as a chemical tool to assess TBK1 as a target in mutant K-Ras cancer cells.

COMPOUNDS FOR THE MODULATION OF RIP2 KINASE ACTIVITY

The present invention relates to compounds, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, for example as inhibitors of the activity of RIP2 kinase, including degrading RIP2 kinase, the treatment of diseases and conditions mediated by the RIP2 kinase, in particular for the treatment of inflammatory diseases or conditions.