169756-84-7Relevant academic research and scientific papers
4-Alkylidenyl glutamic acids, potent and selective GluR5 agonists
Baker,Bleakman, David,Ezquerra, Jesus,Ballyk, Barbara A.,Deverill, Michele,Ho, Ken,Kamboj, Rajender K.,Collado, Ivan,Dominguez, Carmen,Escribano, Ana,Mateo, Ana I.,Pedregal, Concepcion,Rubio, Almudena
, p. 1807 - 1810 (2007/10/03)
Twenty-four 4-alkylidene glutamic acids were synthesised and tested as potential subtype selective GluR5 and 6 ligands. It was found that a critical size of alkylidene group gave potent and selective GluR5 receptor agonists. LY339624 had K(i)s of 0.0326 and > 100 μM on GluR5 and 6 receptors, respectively. (C) 2000 Published by Elsevier Science Ltd. All rights reserved.
Pharmaceutical compounds
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, (2008/06/13)
A pharmaceutical compound of the formula: STR1 in which n is 1 or 2, R1 is --CO2 H, R2 is hydrogen or C1-4 alkyl and R3 is hydrogen, C1-10 alkyl, C2-10 alkenyl, optionally substituted phenyl, optionally substituted phenyl-C1-4 alkyl, optionally substituted phenyl C2-10 alkenyl,(optionally substituted phenyl)2 -C1-4 alkyl, optionally substituted C3-7 cycloalkyl, optionally substituted C3-7 cycloalkyl-C1-4 alkyl or optionally substituted C3-7 cycloalkyl-C2-10 alkenyl, or R2 and R3, together with the carbon atom to which they are attached, form an optionally substituted C4-7 cycloalkyl group; or a salt or ester thereof other than the compounds γ-propylidene-L-glutamic acid, γ-ethylidene-L-glutamic acid and γ-methylidene-L-glutamic acid.
