16979-62-7

Basic information

• Product Name: 7-methoxytryptophan
• CAS NO: 16979-62-7
• Molecular Formula: C₁₂H₁₄N₂O₃
• Molecular Weight: 234.2512
• Mol File: 16979-62-7.mol

Chemical Properties

• Boiling Point: 478.3°C at 760 mmHg
• Flash Point: 243.1°C
• Density: 1.347g/cm³
• Vapor Pressure: 5.87E-10mmHg at 25°C
• Refractive Index: 1.663
• CAS DataBase Reference: 7-methoxytryptophan(CAS DataBase Reference)
• NIST Chemistry Reference: 7-methoxytryptophan(16979-62-7)
• EPA Substance Registry System: 7-methoxytryptophan(16979-62-7)

Safety Data

• Hazardous Substances Data: 16979-62-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
7-methoxytryptophan is used as a therapeutic agent for the treatment of depression and other mood disorders due to its role as a precursor in serotonin biosynthesis. Its potential in modulating neurotransmitter levels and improving mood regulation makes it a valuable compound in this field.
Used in Nutritional Industry:
7-methoxytryptophan is used as a dietary supplement to support overall brain health and cognitive function. Its antioxidant properties and potential role in the biosynthesis of serotonin contribute to its benefits in maintaining optimal brain function and reducing the risk of neurodegenerative disorders.
Used in Metabolic Disorders Treatment:
7-methoxytryptophan is used as a therapeutic agent in the treatment of various metabolic disorders. Its potential to modulate metabolic pathways and improve overall metabolic health makes it a promising compound for addressing these conditions.
Used in Inflammatory Conditions Treatment:
7-methoxytryptophan is used as an anti-inflammatory agent in the treatment of various inflammatory conditions. Its potential to modulate inflammatory pathways and reduce inflammation-related symptoms makes it a valuable compound in this area.

Upstream product

• 94438-01-4 acetylamino-(7-methoxy-indol-3-ylmethyl)-malonic acid diethyl ester 
• 3189-22-8 7-methoxy-1H-indole 
• 46388-50-5 (7-methoxy-1H-indol-3-yl)-N,N-dimethylmethanamine 
• 16979-61-6 formylamino-(7-methoxy-indol-3-ylmethyl)-malonic acid diethyl ester 

Relevant articles and documents

Inhibitors of cellular necrosis

The present invention relates to compounds and pharmaceutical preparations and their use in therapy for preventing or treating trauma, ischemia, stroke and degenerative diseases associated with cell death. Methods and compositions of the invention are particularly useful for treating neurological disorders associated with cellular necrosis.

Structure-activity relationship study of novel necroptosis inhibitors

Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. It can be induced in a FADD-deficient variant of human Jurkat T cells treated with TNF-α. 5-(1H-Indol-3-ylmethyl)-2-thiohydantoins and 5-(1H-indol-3-ylmethyl)hydantoins were found to be potent necroptosis inhibitors (called necrostatins). A SAR study revealed that several positions of the indole were intolerant of substitution, while small substituents at the 7-position resulted in increased inhibitory activity. The hydantoin ring was also quite sensitive to structural modifications. A representative member of this compound class demonstrated moderate pharmacokinetic characteristics and readily entered the central nervous system upon intravenous administration.