16979-62-7

Basic information

• Product Name: 7-methoxytryptophan
• CAS NO: 16979-62-7
• Molecular Formula: C₁₂H₁₄N₂O₃
• Molecular Weight: 234.2512
• Mol File: 16979-62-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 478.3°C at 760 mmHg
• Flash Point: 243.1°C
• Density: 1.347g/cm³
• Vapor Pressure: 5.87E-10mmHg at 25°C
• Refractive Index: 1.663
• CAS DataBase Reference: 7-methoxytryptophan(CAS DataBase Reference)
• NIST Chemistry Reference: 7-methoxytryptophan(16979-62-7)
• EPA Substance Registry System: 7-methoxytryptophan(16979-62-7)

Safety Data

• Hazardous Substances Data: 16979-62-7(Hazardous Substances Data)

Usage

General Description

7-methoxytryptophan is a chemical compound that is derived from the amino acid tryptophan. It is a naturally occurring compound and is often used as a precursor in the biosynthesis of the neurotransmitter serotonin. 7-methoxytryptophan has been studied for its potential therapeutic applications, particularly in the treatment of depression and other mood disorders. It has also been shown to have antioxidant properties and may play a role in supporting overall brain health. Additionally, 7-methoxytryptophan has been investigated for its potential use in the treatment of various metabolic disorders and inflammatory conditions. Overall, 7-methoxytryptophan is a promising compound with potential applications in both the pharmaceutical and nutritional industries.

Upstream product

• 16979-61-6 formylamino-(7-methoxy-indol-3-ylmethyl)-malonic acid diethyl ester 
• 46388-50-5 (7-methoxy-1H-indol-3-yl)-N,N-dimethylmethanamine 
• 3189-22-8 7-methoxy-1H-indole 
• 94438-01-4 acetylamino-(7-methoxy-indol-3-ylmethyl)-malonic acid diethyl ester 

Relevant articles and documents

Structure-activity relationship study of novel necroptosis inhibitors

Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. It can be induced in a FADD-deficient variant of human Jurkat T cells treated with TNF-α. 5-(1H-Indol-3-ylmethyl)-2-thiohydantoins and 5-(1H-indol-3-ylmethyl)hydantoins were found to be potent necroptosis inhibitors (called necrostatins). A SAR study revealed that several positions of the indole were intolerant of substitution, while small substituents at the 7-position resulted in increased inhibitory activity. The hydantoin ring was also quite sensitive to structural modifications. A representative member of this compound class demonstrated moderate pharmacokinetic characteristics and readily entered the central nervous system upon intravenous administration.