169815-81-0

Basic information

• Product Name: Furo[2,3-b]pyridine-5-methanol (9CI)
• Synonyms: Furo[2,3-b]pyridine-5-methanol (9CI);furo[2,3-b]pyridin-5-ylmethanol
• CAS NO: 169815-81-0
• Molecular Formula: C8H7NO2
• Molecular Weight: 149.14668
• Product Categories: PYRIDINE
• Mol File: 169815-81-0.mol

Chemical Properties

• Boiling Point: 284.1±25.0 °C(Predicted)
• Appearance: /
• Density: 1.315±0.06 g/cm3(Predicted)
• PKA: 13.56±0.10(Predicted)
• CAS DataBase Reference: Furo[2,3-b]pyridine-5-methanol (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Furo[2,3-b]pyridine-5-methanol (9CI)(169815-81-0)
• EPA Substance Registry System: Furo[2,3-b]pyridine-5-methanol (9CI)(169815-81-0)

Safety Data

• Hazardous Substances Data: 169815-81-0(Hazardous Substances Data)

Upstream product

• 160729-90-8 ethyl furo<2,3-b>pyridyne-5-carboxylate 
• 170959-86-1 furo<2,3-b>pyridine-2,5-dicarboxylic acid 5-ethyl ester 
• 124031-00-1 4-chlorofuro<2,3-b>pyridine-2,5-dicarboxylicacid 5-ethyl 2-methyl ester 
• 170959-85-0 4-hydroxyfurol<2,3-b>pyridine-2,5-dicarboxylic acid 5-ethyl 2-methyl ester 
• 170959-84-9 (((5-(methoxycarbonyl)-2-furanyl)amino)methylene)propanedioic acid diethyl ester 
• 169815-80-9 methyl furo[2,3-b]pyridine-5-carboxylate 
• 5006-66-6 6-hydroxynicotinic acid 
• 18617-50-0 1-ethyl-2-pyridone-5-carboxylic acid 
• 160729-80-6 ethyl 1,6-dihydro-5-iodo-6-oxo-3-pyridinecarboxylate 
• 160729-79-3 ethyl 6-oxo-5-((trimethylsilyl)ethynyl)-1,6-dihydropyridine-3-carboxylate 
• 122535-07-3 furo[2,3-b]pyridine-2,5-dicarboxylic acid 
• 6562-80-7 diethyl furo<2,3-b>pyridine-2,5-dicarbaxylate 
• 122534-94-5 furo[2,3-b]pyridine-5-carboxylic acid 

Downstream Products

• 201470-89-5 5-formylfuro<2,3-b>pyridine 

Relevant articles and documents

A practical synthesis of the 5-chloromethyl-furo[2,3-b]pyridine pharmacophore

Synthesis of the furopyridine 2 was accomplished in 52% overall yield from 6-hydroxynicotinic acid (3). The synthesis is highlighted by a Heck coupling of 5 with ethylene followed by an NCS mediated oxidative cyclization and elimination sequence.

SPIRO-OXADIAZOLINE COMPOUNDS AS AGONISTS OF α-7-NICOTINIC ACETYLCHOLINE RECEPTORS

The present invention relates to novel spiro-oxadiazoline compounds that are suitable as agonists or partial agonists of a7-nAChR, and pharmaceutical compositions of the same, methods of preparing these compounds and compositions, and the use of these compounds and compositions in methods of maintaining, treating and/or improving cognitive function. In particular, methods of administering a spiro-oxadiazoline cx7-nAChR agonist or partial agonist, to a patient in need thereof, for example a patient with a cognitive deficiency and/or a desire to enhance cognitive function, that may derive a benefit therefrom.

BRIDGED SIX-MEMBERED RING COMPOUNDS

The invention relates to compounds of formula (I), wherein R1, R2, R1a, R2a, R3, R4, A, B, X, W and n are as defined in the description, and pharmaceutically acceptable salts of such compounds. These compounds are useful as calcium channel blockers.

HIV protease inhibitors useful for the treatment of AIDS

Compounds of formula STR1 are HIV protease inhibitors. These compounds are useful in the prevention or treatment of infection by HIV and in the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredien

HIV protease inhibitors useful for the treatment of AIDS

Compounds of formula STR1 are HIV protease inhibitors. These compounds are useful in the prevention or treatment of infection by HIV and in the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.

Method of synthesizing furo[2,3-b]pyridine carboxylic acid esters

A process is disclosed for rapid synthesis of substituted furanyl pyridines.

A practical synthesis of 5-(chloromethyl)furo[2,3-b]pyridine, a key intermediate for the HIV protease inhibitor, L-754,394

A practical synthesis of 5-(chloromethyl)furo[2,3-b]pyridine (10), the side chain used to incorporate a key pharmacophore of the HIV protease inhibitor, L-754,394, is described. The synthesis was accomplished in ten steps and in 15% overall yield from com