6562-80-7Relevant academic research and scientific papers
A practical synthesis of 5-(chloromethyl)furo[2,3-b]pyridine, a key intermediate for the HIV protease inhibitor, L-754,394
Bhupathy,Conlon,Wells,Nelson,Reider,Rossen,Sager,Volante,Dorsey,Hoffman Jr.,Joseph,McDaniel
, p. 1283 - 1287 (2007/10/03)
A practical synthesis of 5-(chloromethyl)furo[2,3-b]pyridine (10), the side chain used to incorporate a key pharmacophore of the HIV protease inhibitor, L-754,394, is described. The synthesis was accomplished in ten steps and in 15% overall yield from com
