169882-27-3Relevant academic research and scientific papers
1N-ALKYL-N-ARYLPYRIMIDINAMINES AND DERIVATIVES THEREOF
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Example 101, (2010/01/30)
The present invention provides novel compounds, compounds and pharmaceutical compositions thereof, and methods of using same in the treatment of affective disorders, anxiety, depression, post-traumatic stress disorders, eating disorders, supranuclear palsy, irritable bowel syndrome, immune suppression, Alzheimer'disease, gastrointestinal diseases, anorexia nervosa, drug and alcohol withdrawal symptoms, drug addiction, inflammatory disorders, or fertility problems. The novel compounds provided by this invention are those of formula: wherein R 1, R 3, R 4, R 5, Z, Y, V, X, X', J, K, L, and M are as defined herein.
1N-alkyl-N-arylpyrimidinamines and derivatives thereof
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, (2008/06/13)
The present invention provides novel compounds, compounds and pharmaceutical compositions thereof, and methods of using same in the treatment of affective disorders, anxiety, depression, post-traumatic stress disorders, eating disorders, supranuclear palsy, irritable bowel syndrome, immune suppression, Alzheimer's disease, gastrointestinal diseases, anorexia nervosa, drug and alcohol withdrawal symptoms, drug addiction, inflammatory disorders, or fertility problems. The novel compounds provided by this invention are those of formula: wherein R1, R3, R4, R5, Z, Y, V, X, X', J, K, L, and M are as defined herein.
Synthesis, corticotropin-releasing factor receptor binding affinity, and pharmacokinetic properties of triazolo-, imidazo-, and pyrrolopyrimidines and -pyridines
Chorvat, Robert J.,Bakthavatchalam, Rajagopal,Beck, James P.,Gilligan, Paul J.,Wilde, Richard G.,Cocuzza, Anthony J.,Hobbs, Frank W.,Cheeseman, Robert S.,Curry, Matthew,Rescinito, Joseph P.,Krenitsky, Paul,Chidester, Dennis,Yarem, Jerry A.,Klaczkiewicz, John D.,Hodge, C. Nicholas,Aldrich, Paul E.,Wasserman, Zelda R.,Fernandez, Christine H.,Zaczek, Robert,Fitzgerald, Lawrence W.,Huang, Shiew-Mei,Shen, Helen L.,Wong, Y. Nancy,Chien, Ben M.,Quon, Check Y.,Arvanitis, Argyrios
, p. 833 - 848 (2007/10/03)
The synthesis and CRF receptor binding affinities of several new series of N-aryltriazolo- and -imidazopyrimidines and -pyridines are described. These cyclized systems were prepared from appropriately substituted diaminopyrimidines or -pyridines by nitrous acid, orthoester, or acyl halide treatment. Variations of amino (ether) pendants and aromatic substituents have defined the structure-activity relationships of these series and resulted in the identification of a variety of high-affinity agents (K(i)'s 1 has been selected for further pharmacological studies that will be reported in due course.
