169894-65-9Relevant academic research and scientific papers
An expeditious and convenient synthesis of acylsulfonamides utilizing polymer-supported reagents
Wang, Ying,Sarris, Kathy,Sauer, Daryl R.,Djuric, Stevan W.
, p. 5181 - 5184 (2008/02/08)
Acylsulfonamides can be rapidly and conveniently synthesized from a variety of carboxylic acids and sulfonamides utilizing the commercially available reagents, PS-DCC and DMAP under mild reaction conditions. DMAP can be efficiently scavenged by utilizatio
A STUDY OF TRANSMISSION EFFECTS OF SULFONYL AND CARBONYL GROUPS
Ludwig, Miroslav,Parik, Patrik,Kulhanek, Jiri
, p. 841 - 850 (2007/10/02)
Seventeen p-substituted N-phenylsulfonylbenzamides of general formulas XC6H4SO2NHCOC6H5 and C6H5SO2NHCOC6H4X have been synthesized and their structure has been confirmed by elemental analysis and 1H NMR spectra.The dissociation constants of all compounds have been measured by potentiometric titration in methanol, acetonitrile, dimethylformamide, dimethyl sulfoxide, and pyridine.The obtained pKHA values have been correlated with three sets of Hammett substituent constants using simple or double linear regression.The solvent and substituent effects are discussed on the basis of experimental results, and the difference between the substituent effects from sulfonamide and benzamide sections is evaluated.It has been found that due to extensive delocalization of negative charge in the conjugated base the transmission effects of carbonyl and sulfonyl groups on the transmission of substituent effect are roughly the same.The experimental data have been interpreted by the methods with latent variables: the principal component analysis (PCA), the conjugated deviation analysis (CDA), and the method of projection to latent structures (PLS).The results obtained by these procedures were similar.
