16990-73-1 Usage
General Description
1H-Indol-2-ol, also known as oxindole, is a chemical compound with the molecular formula C8H7NO. It is a derivative of indole, a heterocyclic aromatic organic compound. 1H-Indol-2-ol is commonly found in a variety of natural products and has shown potential pharmacological activities, including antioxidant, anti-inflammatory, and anticancer properties. It serves as a key building block for the synthesis of various pharmaceuticals and agrochemicals. Its unique structure and versatile reactivity make it an important intermediate for the production of a wide range of biologically active compounds. Overall, 1H-Indol-2-ol is a valuable chemical compound with diverse applications in the fields of medicine, agriculture, and materials science.
Check Digit Verification of cas no
The CAS Registry Mumber 16990-73-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,9,9 and 0 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 16990-73:
(7*1)+(6*6)+(5*9)+(4*9)+(3*0)+(2*7)+(1*3)=141
141 % 10 = 1
So 16990-73-1 is a valid CAS Registry Number.
InChI:InChI=1/C8H7NO/c10-8-5-6-3-1-2-4-7(6)9-8/h1-5,9-10H
16990-73-1Relevant articles and documents
Directed evolution of the fatty-acid hydroxylase P450 BM-3 into an indole-hydroxylating catalyst
Li, Qing-Shan,Schwaneberg, Ulrich,Fischer, Peter,Schmid, Rolf D.
, p. 1531 - 1536 (2007/10/03)
The self-sufficient cytochrome P450 BM-3 enzyme from Bacillus megaterium catalyzes subterminal hydroxylation of saturated long-chain fatty acids and structurally related compounds. Since the primary structure of P450 BM-3 is homologous to that of mammalian P450 type II, it represents an excellent model for this family of enzymes. During studies on the directed evolution of P450 BM-3 into a medium-chain fatty-acid hydroxylase, several mutants, in particular the triple mutant Phe87Val, Leu 188Gln, Ala74Gly, were observed to hydroxylate indole, producing indigo and indiruhin at a catalytic efficiency of 1365M-1s-1 (kcat=2.73 s-1 and Km,=2.0mM). Both products were unequivocally characterized by NMR and MS analysis. Wild-type P450 BM-3 is incapable to hydroxylate indole. These results demonstrate that an enzyme can be engineered to catalyze the transformation of substrates with structures widely divergent from those of its native substrate.
