97207-47-1

Basic information

• Product Name: Meisoindigo
• Synonyms: 1-METHYL-3,3'-BIINDOLE-2,2'(1H,1'H)-DIONE;3-(1,2-dihydro-2-oxo-3h-indol-3-ylidene)-1,3-dihydro-1-methyl-2h-indol-2-one;MEISOINDIGO;N-methylisoindigotin;Dian III;Methylisoindigotin;Natura-α;Meisoindigo 3-(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)-1,3-dihydro-1-methyl-2H-indol-2-one
• CAS NO: 97207-47-1
• Molecular Formula: C₁₇H₁₂N₂O₂
• Molecular Weight: 276.29
• EINECS: 200-256-5
• Product Categories: Inhibitors
• Mol File: 97207-47-1.mol

Chemical Properties

• Melting Point: 236-237°C
• Boiling Point: 482 °C at 760 mmHg
• Flash Point: 245.3 °C
• Appearance: /
• Density: 1.381 g/cm³
• Vapor Pressure: 1.89E-09mmHg at 25°C
• Refractive Index: 1.698
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: insoluble in H2O; insoluble in EtOH; ≥25.85 mg/mL in DMSO with ultrasonic
• CAS DataBase Reference: Meisoindigo(CAS DataBase Reference)
• NIST Chemistry Reference: Meisoindigo(97207-47-1)
• EPA Substance Registry System: Meisoindigo(97207-47-1)

Safety Data

• Hazardous Substances Data: 97207-47-1(Hazardous Substances Data)

Usage

Description

Meisoindigo is a derivative of indirubin that has anticancer activity. It inhibits the growth of NB4, HL-60, and U937 leukemia and primary acute myeloid leukemia (AML) cells when used at concentrations of 5 and 10 μM. It also halts the cell cycle at the G0/G1 phase and induces apoptosis in leukemia cell lines and primary AML cells, induces myeloid differentiation, and potentiates the effects of cytarabine and idarubicin . Meisoindigo (10 μM) also induces apoptosis, decreases adherence, and decreases the expression of vascular cell adhesion molecule-1 (VCAM-1) in ECV304 human vein endothelial cells. Meisoindigo (50-150 mg/kg per day) decreases spleen size in an HL-60 mouse xenograft model of AML in a dose-dependent manner.

Chemical Properties

mp 236-237°C

Uses

Different sources of media describe the Uses of 97207-47-1 differently. You can refer to the following data:
1. Meisoindigo is a 5-HT3 receptor antagonist prevents acute nausea and vomiting associated with emetogenic cancer chemotherapy
2. Meisoindigo shows strong anti-proliferation effect against gemcitabine-resistant Pancreatic ductal adenocarcinoma (PDACs).

references

[1] lee cc, lin cp, lee yl, wang gc, cheng yc, liu he. meisoindigo is a promising agent with in vitro and in vivo activity against human acute myeloid leukemia. leuk lymphoma. 2010 may;51(5):897-905.

InChI:InChI=1/C17H12N2O2/c1-19-13-9-5-3-7-11(13)15(17(19)21)14-10-6-2-4-8-12(10)18-16(14)20/h2-9H,1H3,(H,18,20)/b15-14+