169904-05-6

Basic information

• Product Name: Benzene, 1-(5-bromo-1-pentenyl)-4-fluoro-, (E)-
• CAS NO: 169904-05-6
• Molecular Formula: C11H12BrF
• Molecular Weight: 243.119
• Mol File: 169904-05-6.mol

Chemical Properties

• CAS DataBase Reference: Benzene, 1-(5-bromo-1-pentenyl)-4-fluoro-, (E)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(5-bromo-1-pentenyl)-4-fluoro-, (E)-(169904-05-6)
• EPA Substance Registry System: Benzene, 1-(5-bromo-1-pentenyl)-4-fluoro-, (E)-(169904-05-6)

Safety Data

• Hazardous Substances Data: 169904-05-6(Hazardous Substances Data)

Upstream product

• 405-99-2 para-fluorostyrene 
• 1119-51-3 bromopentene 

Relevant articles and documents

Synthesis of combretastatin A-4 O-alkyl derivatives and evaluation of their cytotoxic, antiangiogenic and antitelomerase activity Dedicated to Professor G. Asensio, University of Valencia, on the occasion of his 65th birthday

We here report the synthesis and biological evaluation of several combretastatin A-4 derivatives alkylated at the phenol hydroxyl group. Some of these derivatives contain an (E)-arylalkene fragment reminiscent of that present in some natural stilbenes like resveratrol. The cytotoxicities towards one human healthy kidney embryonic and two tumoral cell lines were determined. In addition, the ability of these compounds to inhibit the production of the vascular endothelial growth factor (VEGF) was measured. Finally, the expression of genes controlling the production of telomerase was measured. Some of the compounds were found to have an activity comparable or higher than that of combretastatin A-4 in at least one of the aforementioned biological properties. The compounds with the (E)-arylalkene fragment were in general terms more active than the simple O-alkyl derivatives. However, no clear structure/activity correlations were perceived when comparing the observed compound activities across the three biological properties. This points out the existence of marked differences between the mechanisms responsible for their cytotoxicity.

Unsymmetrical cyclic diamine compound

A cyclic diamine compound of formula (1): wherein A is (CH2)n, (CH2)n—CH═CH, CO—(CH2)n or CO—(CH2)n—CH═CH, in which n is a number of 0 to 3; Z represents a formula (2) or (3): in which R1, R2, R4, R5 and R6 are individually a hydrogen atom, alkyl group, alkoxy group, halogen atom or nitro group; R3 is a hydrogen atom, alkyl group, alkoxy group, halogen atom, nitro group, naphthyl group, or phenyl group which may be substituted by 1 to 3 substituents selected from the group consisting of alkyl groups, alkoxy groups, halogen atoms, a nitro group and a phenyl group; and X and Y are individually CH or a nitrogen atom; and m is 1 or 2; an acid-addition salt thereof, or a hydrate thereof, and a medicine containing such a compound.