169949-48-8

Upstream product

• 169949-49-9 2-(Benzhydrylidene-amino)-3-(3-cyano-phenyl)-propionic acid ethyl ester 
• 69555-14-2 ethyl N-diphenylmethylene glycine 
• 28188-41-2 m-(bromomethyl)benzonitrile 

Downstream Products

• 57213-48-6 3-cyano-(D,L)-phenylalanine 
• 214842-56-5 2-[2-(4-Thiocarbamoyl-benzenesulfonylamino)-acetylamino]-3-(3-thiocarbamoyl-phenyl)-propionic acid ethyl ester 
• 214842-42-9 2-[2-(4-Cyano-benzenesulfonylamino)-acetylamino]-3-(3-cyano-phenyl)-propionic acid ethyl ester 

Relevant academic research and scientific papers

USP30 INHIBITORS

The application relates to phenyl- or naphthylsulfonamide derivatives of the structural formula (I). The compounds are described as inhibitors of USP30 (ubiquitin specific peptidase 30) useful for the treatment of conditions involving mitochondrial defects including neurodegenerative diseases such as Alzheimer's and Parkinson's or a neoplastic disease such as leukemia.

Design of benzamidine-type inhibitors of factor Xa

A series of derivatives of rac-benzenesulfonyl-glycyl-phenylalanine or its ethyl ester with a combination of thioamido/amidino or amidino/amidino substituents in the benzene rings was synthesized as potential inhibitors of factor Xa (fXa). Among these, th