17001-26-2Relevant academic research and scientific papers
Isolation of Five-Membered Cyclitol Glycolipids, Crasserides: Unique Glycerides from the Sponge Pseudoceratina crassa
Constantino, Valeria,Fattorusso, Ernesto,Mangoni, Alfonso
, p. 186 - 191 (1993)
Crasserides 1a-6a, six new glycolipid analogues in which the sugar moiety is replaced by an unprecedented five-membered cyclitol, were isolated as a mixture from the sponge Pseudoceratina crassa (Hyatt), and their structures were determined by spectroscopic and chemical analysis.Compounds 1a-6a showed a high antifeedant activity on the fish Carassius auratus, which suggests their potential role as natural feeding deterrents.
Synthesis of specific deuterated derivatives of the long chained stratum corneum lipids [EOS] and [EOP] and characterization using neutron scattering
Sonnenberger, Stefan,Eichner, Adina,Schmitt, Thomas,Hau?, Thomas,Lange, Stefan,Langner, Andreas,Neubert, Reinhard H.H.,Dobner, Bodo
, p. 316 - 330 (2017/06/08)
The synthesis of specific deuterated derivatives of the long chained ceramides [EOS] and [EOP] is described. The structural differences with respect to the natural compounds are founded in the substitution of the 2 double bonds containing linoleic acid by a palmitic acid branched with a methyl group in 10-position. The specific deuteration is introduced both in the branched and in the terminal methyl group, which was realized by common methods of successive deuteration of carboxylic groups in 3 steps. These modified fatty acids resp. the corresponding ceramides [EOS] and [EOP] were prepared for neutron scattering investigations. First results of these investigations were presented in this manuscript showing that the deuterated compounds could be detected in the stratum corneum lipid model membranes. The deuterated ceramides [EOS] and [EOP] are valuable tools to investigate the influence of these long chained ceramide species on the nanostructure of stratum corneum lipid model membranes.
