170033-63-3

Upstream product

• 103-49-1 dibenzylamine 
• 170033-50-8 (S)-<2--1-methyl-2-oxoethyl>carbamic acid 1,1-dimethylethyl ester 

Downstream Products

• 170211-03-7 (3R,5R)-3,5-Dimethyl-1-(phenylmethyl)piperazine 
• 1231709-78-6 C₁₄H₂₂N₂O₂ 
• 170033-51-9 (S)-2-Amino-1-propane 
• 170033-52-0 (S)-N-<2--1-methylethyl>-L-alanine methyl ester 
• 170211-02-6 (3S,5S)-3,5-Dimethyl-1-(phenylmethyl)piperazin-2-one 
• 162240-95-1 (3S,5S)-3,5-Dimethyl-1-(phenylmethyl)piperazine 

Relevant academic research and scientific papers

QUINOLINE DERIVATIVES AS SMO INHIBITORS

Disclosed are quinoline derivatives as hedgehog pathway inhibitors, especially as SMO inhibitors. Compounds of the present invention can be used in treating diseases relating to hedgehog pathway including cancer.

Discovery of a piperazine urea based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist

We report the discovery of piperazine urea based compound 1, a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist. Compound 1 shows anti-obesity efficacy without potentiating erectile activity in the rodent models.

Simple highly modular acyclic amine-catalyzed direct enantioselective addition of ketones to nitro-olefins

Simple, highly modular primary amino acid derivatives catalyze the direct enantioselective addition of ketones to nitro-olefins with high stereocontrol and furnish the corresponding aldol products in high yield with up to >38 : 1 dr and up to 99% ee. The

Asymmetric Synthesis of 2,6-Methylated Piperazines

The complete series of enantiopure 2,6-methylated piperazines was synthesized utilizing two alternative reactions in the key bond-forming step.The dimethyl enantiomers, (2R,6R)- and (2S,6S)-2,6-dimethylpiperazine (1, 2), were prepared using either a diastereoselective triflate alkylation or a novel intermolecular Mitsunobu reaction to set the required stereochemistry.The monomethyl derivatives, (R)- and (S)-tert-butyl 2-methyl-1-piperazinecarboxylate (3, 4) were also synthesized employing the Mitsunobu cyclization strategy while the trimethyl compounds, (R)- and (S)-2,2,6- trimethylpiperazine (5, 6) were prepared using an enantiospecific triflate alkylation as the principal reaction.These methods represent efficient, general strategies for preparing a variety of 2,6-methylated piperazines for which the absolute stereochemistry can be readily controlled.

Asymmetric Synthesis of (2R,6R) and (2S,6S)-2,6-Dimethylpiperazine

The title compounds were prepared via two efficient routes.The first sequence utilized a diastereospecific triflate alkylation in the key bond forming step while the second method relied on a novel intramolecular Mitsunobu reaction to set the required stereochemistry.