1700693-08-8 Usage
Description
JH-II-127 is an orally bioavailable inhibitor of wild-type (WT) and mutant forms of leucine-rich repeat kinase 2 (LRRK2). It inhibits WT LRRK2, as well as LRRK2 containing the G2019S and A2016T substitution mutations (IC50s = 6.6, 2.2, and 47.7 nM, respectively), which are present in certain patients with Parkinson’s disease, but not LRRK2 containing both mutations (IC50 = 3,080 nM). JH-II-127 (0.1-0.3 μM) inhibits phosphorylation of the serines at positions 910 and 935 of WT LRRK2 and LRRK2G2019S in vitro. It also inhibits Ser935 phosphorylation in vivo in mouse brain, spleen, and kidney when administered at a dose of 30 mg/kg.
Uses
JH-II-127 is a highly potent, selective, and brain penetrant LRRK2 inhibitor.
Check Digit Verification of cas no
The CAS Registry Mumber 1700693-08-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,7,0,0,6,9 and 3 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1700693-08:
(9*1)+(8*7)+(7*0)+(6*0)+(5*6)+(4*9)+(3*3)+(2*0)+(1*8)=148
148 % 10 = 8
So 1700693-08-8 is a valid CAS Registry Number.
1700693-08-8Relevant articles and documents
LRRK2 INHIBITORS AND METHODS OF MAKING AND USING THE SAME
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Page/Page column 116; 117, (2016/09/22)
Compounds having the formula (I), (II), (III) are provided. Compounds of the present disclosure are useful for the treatment of neurodegenerative diseases, such as Parkinson's Disease.
