1700693-08-8 Usage
Uses
Used in Pharmaceutical Industry:
JH-II-127 is used as a therapeutic agent for the treatment of Parkinson's disease. Its application is based on its ability to inhibit LRRK2, a protein that is implicated in the pathology of the disease. By targeting LRRK2, JH-II-127 has the potential to slow down or halt the progression of Parkinson's disease, particularly in patients with specific LRRK2 mutations.
Additionally, JH-II-127's brain penetrant properties make it a valuable candidate for the development of treatments for other neurological disorders where LRRK2 inhibition may be beneficial.
Check Digit Verification of cas no
The CAS Registry Mumber 1700693-08-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,7,0,0,6,9 and 3 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1700693-08:
(9*1)+(8*7)+(7*0)+(6*0)+(5*6)+(4*9)+(3*3)+(2*0)+(1*8)=148
148 % 10 = 8
So 1700693-08-8 is a valid CAS Registry Number.
1700693-08-8Relevant academic research and scientific papers
LRRK2 INHIBITORS AND METHODS OF MAKING AND USING THE SAME
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Page/Page column 116; 117, (2016/09/22)
Compounds having the formula (I), (II), (III) are provided. Compounds of the present disclosure are useful for the treatment of neurodegenerative diseases, such as Parkinson's Disease.
Discovery of a pyrrolopyrimidine (JH-II-127), a highly potent, selective, and brain penetrant LRRK2 inhibitor
Hatcher, John M.,Zhang, Jinwei,Choi, Hwan Geun,Ito, Genta,Alessi, Dario R.,Gray, Nathanael S.
supporting information, p. 584 - 589 (2015/05/27)
Activating mutations in leucine-rich repeat kinase 2 (LRRK2) are present in a subset of Parkinson's disease (PD) patients and may represent an attractive therapeutic target. Here we report a 2-anilino-4-methylamino-5-chloropyrrolopyrimidine, JH-II-127 (18
