17012-49-6

Basic information

• Product Name: 5,7-Dibromo-8-methoxyquinoline
• Synonyms: 5,7-Dibromo-8-methoxyquinoline
• CAS NO: 17012-49-6
• Molecular Formula: C₁₀H₇Br₂NO
• Molecular Weight: 316.98
• Mol File: 17012-49-6.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5,7-Dibromo-8-methoxyquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 5,7-Dibromo-8-methoxyquinoline(17012-49-6)
• EPA Substance Registry System: 5,7-Dibromo-8-methoxyquinoline(17012-49-6)

Safety Data

• Hazardous Substances Data: 17012-49-6(Hazardous Substances Data)

Usage

General Description

5,7-Dibromo-8-methoxyquinoline is a chemical compound with the molecular formula C10H6Br2NO. It is a quinoline derivative that contains two bromine atoms at positions 5 and 7, as well as a methoxy group at position 8. This chemical is commonly used as a research reagent and intermediate in the synthesis of pharmaceuticals and organic compounds. It has been studied for its potential use in the treatment of various diseases and disorders, including cancer and microbial infections. Additionally, 5,7-Dibromo-8-methoxyquinoline has been shown to exhibit antimicrobial and antiproliferative properties, making it a valuable compound for medicinal and industrial applications.

Upstream product

• 938-33-0 8-methoxyquinoline 
• 521-74-4 broxyquinoline 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 

Downstream Products

• 182816-49-5 (5-Bromo-8-methoxy-quinolin-7-yl)-(2-methoxy-phenyl)-methanol 
• 170959-70-3 5-(2-aminophenyl)-7-bromo-8-methoxyquinoline 
• 170959-71-4 5-(2-amino-5-methoxyphenyl)-7-bromo-8-methoxyquinoline 
• 170959-75-8 5-(2-azidophenyl)-7-bromo-8-methoxyquinoline 
• 170959-76-9 5-(2-azido-5-methoxyphenyl)-7-bromo-8-methoxyquinoline 
• 172795-91-4 2,2-dimethyl-N-(2-(8-methoxy-5-phenyl-7-quinolyl)phenyl)propanamide 
• 172795-94-7 7-(2-azidophenyl)-8-methoxy-5-phenylquinoline 
• 172795-92-5 7-(2-aminophenyl)-5-phenyl-8-methoxyquinoline 
• 182816-50-8 (5-Bromo-8-methoxy-quinolin-7-yl)-(2-methoxy-phenyl)-methanone 
• 170959-58-7 7-bromo-5-phenyl-8-methoxyquinoline 
• 170959-65-6 2,2-dimethyl-N-(2-(7-bromo-8-methoxy-5-quinolinyl)-4-methoxyphenyl)propanamide 
• 170959-64-5 2,2-dimethyl-N-(2-(7-bromo-8-methoxy-5-quinolinyl)phenyl)propanamide 

Relevant articles and documents

Efficient relay syntheses and assessment of the DNA-cleaving properties of the pyrrole alkaloid derivatives permethyl storniamide A, lycogalic acid A dimethyl ester, and the halitulin core

Palladium catalyzed Suzuki- and Negishi cross coupling reactions are used to convert the now readily available 3,4-dibromopyrrole derivatives 13 and 26 into the core structures of different pyrrole alkaloids. Several compounds of this series exhibit respe

A SAR study: Evaluation of bromo derivatives of 8-substituted quinolines as novel anticancer agents

Background: Brominated 8-hydroxy, 8-methoxy, 8-amino quinolines 5, 6, 8, 9 and novel cyano 8-hydroxyquinolines 11, 12 were evaluated in vitro for their anticancer effects on various cell lines. 5, 7-Dibromo- 5, 7-bromo- 6, 7-cyano- 11 and 5, 7-dicyano-12 8-hydroxyquinolines were shown to have strong antiproliferative activity against various tumor cell lines, including C6 (rat brain tumor), HeLa (human cervix carcinoma), and HT29 (human colon carcinoma) with IC50 values ranged from 6.7 to 25.6 μg/mL. Methods: A structure activity relationship (SAR) was conducted that quinoline core containing hydroxly group at C-8 positon led to more anti cancer potentials. Results: The results of Lactate Dehydrogenase (LDH) cytotoxic, DNA laddering and inhibition assays indicated that 5, 6, 11 and 12 have high cytotoxic effects and appototic potentials. Conclusion: Furthermore, 5 and 12 have inhibitory effects on relaxation of supercoiled plazmid DNA by supressed the Topoisomerase I enzyme. As a result, 5, 6, 11 and 12 may have promising anticancer drug potential and 5 and 12 may be novel topoisomerase inhibitors.

NITROGEN-CONTAINING HETEROARYL COMPOUNDS HAVING HIV INTEGRASE INHIBITORY ACTIVITY

A compound of the formula (I): wherein Z4, Z5 and Z9 each is independently carbon atom or nitrogen atom; Y is hydroxy, mercapto or amino; RA is a group of the formula: (wherein C ring is nitrogen-containing heteroaryl) has an inhibitory activity against integrase.