170127-44-3Relevant academic research and scientific papers
The synthesis and characterization of new triphenylethylene platinum(II) complexes
Berube, Gervais,He, Yuehua,Groleau, Serge,Sene, Alexandre,Therien, Helene-Marie,Caron, Madeleine
, p. 139 - 145 (1997)
In our search for a chemotherapeutic agent with a better therapeutic index and selectivity for the treatment of breast cancer, we have synthesized a series of cytotoxic analogs of tamoxifen. The new triphenylethylene platinum(II) derivatives were designed to possess binding affinity for the estrogen receptor. The synthesis of this type of compound is straightforward and efficient. The new complexes were fully characterized by their IR, 1H NMR and 13C NMR spectra as well as their elemental analysis. The estrogen receptor binding affinity (RBA) of some of these triphenylethylenes was also evaluated and was found to be comparable to the affinity of the reference drug, i.e. tamoxifen, RBA=1.3%.
