17016-86-3

Upstream product

• 19213-72-0 ethyl 1-imidazolecarboxylate 
• 16369-17-8 2-amino-4-methylpentan-1-ol 
• 3647-37-8 2-isobutyl-aziridine 
• 124-38-9 carbon dioxide 
• 98433-24-0 2-hydroxymethyl-4-methyl-pentanoic acid hydrazide 

Downstream Products

• 70468-83-6 {4-[2-methyl-1-(2-oxo-oxazolidin-4-yl)-propoxy]-phenethyl}-carbamic acid tert-butyl ester 
• 70468-82-5 {4-[2-methyl-1-(2-oxo-oxazolidin-4-yl)-propoxy]-phenethyl}-carbamic acid benzyl ester 

Relevant academic research and scientific papers

Chemical fixation of carbon dioxide co-catalyzed by a combination of Schiff bases or phenols and organic bases

Binaphthyldiamino, ethyldiamino and cyclohexyldiamino Schiff bases can catalyze the reaction of epoxides with carbon dioxide in the presence of catalytic amounts of various organic bases to give the corresponding cyclic carbonates in high yields. The simplest binaphthyldiamino Schiff base, derived from the reaction of binaphthyldiamine with salicylaldehyde, gave the highest yield of cyclic carbonate. This catalytic system can be further simplified by use of a phenol instead of the Schiff base to give the corresponding cyclic carbonates in high yields as well. Mechanistic insights were obtained based on a deuterium labeling experiment, The reaction of aziridines with CO2 and epoxide with CS2 were also examined under the same reaction conditions. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.

Method of preparing oxazolidone

The invention discloses a method of preparing oxazolidone. The method uses aziridine and carbon dioxide as materials and imidazole ionic liquid modified Salen metal complex comprising polyether chains as a catalyst, and allows high-efficiency and high-selectivity catalytic synthesis of oxazolidone under a pressure of 0.1-2.0 Mpa at a temperature of 30-70 DEG C; the process has relatively mild reaction conditions, there is no need for any solvent or co-catalyst, and reaction time is short; in addition, the catalyst provided herein can form a homogeneous catalytic system with a substrate under certain temperature and pressure, and by adding the solvent, it is possible to separate from the reaction system to enable reuse.

Ethyl imidazole-1-carboxylate (EImC) as a carbonylating agent: Efficient synthesis of oxazolidin-2-ones from amino alcohols

Various substituted oxazolidin-2-ones were synthesized from the corresponding amino alcohols using ethyl imidazole- 1-carboxylate (EImC). Highly substituted and sterically hindered amino alcohols and amino alcohols having a free hydroxy group were cyclized to oxazolidin-2-ones efficiently. This method is simple and produces oxazolidin-2-ones in very good yield.