17016-88-5

Upstream product

• 64715-76-0 (S)-2-(1-hydroxy-4-methylpentan-2-yl)isoindoline-1,3-dione 
• 3183-10-6 N-phthalimide-L-leucinyl chloride 
• 64490-39-7 N-phthalyl-L-leucinal 
• 2419-38-7 N-phthaloyl-(S)-leucine 
• 7533-40-6 (S)-2-amino-4-methylpentan-1-ol 

Downstream Products

• 103633-09-6 PMZ-His-L-leucinol 
• 132413-82-2 L-Histidyl-L-leucinol di-p-toluenesulfonic Acid 
• 1415990-58-7 Z-Ile-Aib-Pro-Leuol 
• 1415990-59-8 Z-Ile-Aib-Pro-Leuol 

Relevant academic research and scientific papers

One-pot synthesis and biological and catalytic applications of organometallic complexes involving oxazolines and (R)/(S)-a-phenylethylamine

The crystal structures of zinc complexes 1 and 3 were determined following synthesis via a one-pot method involving the reaction of 2-hydro-6-methyl-nicotinonitrile and 2-cyanopyridine with different l-amino alcohols mediated by 120–130?mol% ZnCl2/s

Synthesis method of chiral (S)-leucinol hydrochloride

The invention provides chiral (S)-leucinol hydrochloride. The chemical formula of the chiral (S)-leucinol hydrochloride is shown in the description. A synthesis method of the chiral (S)-leucinol hydrochloride includes synthesis and separation; according to synthesis, after (S)-leucinol and manganese(II) chloride react in an anhydrous methanol solution for 40 hours, a solvent is removed in a rotating mode, dark red solid is obtained, trichloromethane and ethyl alcohol are then added for dissolution, and the product chiral (S)-leucinol hydrochloride is obtained after natural volatilization.

Renin Inhibitors. Substitution of the Leucyl Residues of Leu-Leu-Val-Phe-OCH3 with 3-Amino-2-hydroxy-5-methylhexanoic Acid

The 2S,3S and 2R,3S diastereoisomers of the hydroxy amino acid 3-amino-2-hydroxy-5-methylhexanoic acid (AHMHA) were synthesized and substituted for the leucyl residues of Leu-Leu-Val-Phe-OCH3 to yield the following analogues: AHMHA-Leu-Val-Phe-OCH3, AHMHA