3183-10-6

Basic information

• Product Name: N-phthalimide-L-leucinyl chloride
• Synonyms: N-phthalimide-L-leucinyl chloride
• CAS NO: 3183-10-6
• Molecular Weight: 279.723
• Mol File: 3183-10-6.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: N-phthalimide-L-leucinyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: N-phthalimide-L-leucinyl chloride(3183-10-6)
• EPA Substance Registry System: N-phthalimide-L-leucinyl chloride(3183-10-6)

Safety Data

• Hazardous Substances Data: 3183-10-6(Hazardous Substances Data)

Upstream product

• 85-44-9 phthalic anhydride 

Downstream Products

• 65699-22-1 1-[4-Chloro-2-(2-chloro-benzoyl)-phenyl]-5-{[(S)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-4-methyl-pentanoylamino]-methyl}-1H-[1,2,4]triazole-3-carboxylic acid dimethylamide 
• 126901-06-2 (S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-4-methyl-pentanoic acid hydroxy-p-tolyl-amide 
• 199186-69-1 (R)-6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline 
• 199186-68-0 (S)-6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline 
• 1416475-28-9 (2R,4R,5S)-5-(4-bromophenyl)-4-tert-butoxy-carbonyl-1-[(2'S)-N-phthaloylleucyl]-2-methoxycarbonyl-pyrrolidine 
• 1416475-23-4 (2S,4S,5R)-5-(4-bromophenyl)-4-tert-butoxycarbonyl-1-[(2'S)-N-phthaloylleucyl]-2-methoxycarbonylpyrrolidine 
• 1403673-29-9 (R)-2-methyl-1-[N'-phthaloyl-(S)-leucyl]-1,2,3,4-tetrahydroquinoline 
• 1403673-28-8 (2S,2'S)-2-methyl-1-(N'-phthaloyl-leucyl)-1,2,3,4-tetrahydroquinoline 

Relevant articles and documents

DUAL KINASE-BROMODOMAIN INHIBITORS

Provided herein are compounds of Formula (I) that are dual inhibitors of kinases and bromo-domain proteins. The disclosure also relates to pharmaceutical compositions containing such compounds, methods for using such compounds in the treatment of cancers, particularly, the treatment of multiple myeloma cancers, and to related uses.

1,2-Hydride Migration in Dialkyl α-Diazophosphonates Catalyzed by [Cu(MeCN)4]PF6: A Novel Approach to β-Amino (E)-Enylphosphonates

The regiospecific and stereoselective 1,2-migration reaction of dialkyl α-diazophosphonates for the synthesis of β-amino (E)-enylphosphonates is developed utilizing tetrakis(acetonitrile)copper(I) hexafluorophosphate [Cu(MeCN)4PF6] as the catalyst and N,N-dimethylformamide as an additive. A possible mechanism for the 1,2-migration reaction involving a metal carbene is presented. An investigation on the E/Z isomer selectivity of this process demonstrates that steric factors play an important role on the outcome. This process provides a straightforward access to β-amino (E)-enylphosphonates in moderate to good yields.

Trifluoroborane-catalyzed C-H functionalization/S-H insertion reaction: Construction of N,S-acetal quaternary centers

Abstract The trifluoroborane-catalyzed C-H functionalization/S-H insertion reaction of α-diazophosphonates with thiols has been developed. A plausible reaction mechanism has been proposed to understand the combined reaction. This process provides straightforward access to N,S-acetals containing quaternary centers in moderate to good yields and chemoselectivity.